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PET/CT in Psoriatic Arthritis

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ClinicalTrials.gov Identifier: NCT01654198
Recruitment Status : Active, not recruiting
First Posted : July 31, 2012
Last Update Posted : November 14, 2017
Information provided by (Responsible Party):
University of Pennsylvania

Brief Summary:
When patients with psoriasis develop joint pain, it is often hard to decide whether or not the pain is due to psoriatic arthritis (PsA). At this time, doctors use information from the history and physical exam to determine the diagnosis. X-rays, magnetic resonance imaging (MRI) and ultrasound have been used to help with the diagnosis but all three have limitations. A newer imaging technique, whole body Positron Emission Tomography/Computed Tomography (PET/CT) uses the idea that inflammatory cells take up sugar to locate inflammation in the body. Because patients with PsA have inflammatory cells in their joints and tendons, this type of scan allows the physician to take a picture of the whole body and locate inflammation. The investigators have found that some patients with psoriasis (but without arthritis) have inflammation in joints and tendons even before the patient has symptoms. In this study, the investigators will explore how well PET/CT works for assessing inflammation in patients with PsA. This would be a very exciting tool that could be used to find and treat inflammation before it causes damage or pain.

Condition or disease Intervention/treatment
Psoriatic Arthritis Radiation: FDG-PET/CT scan

Study Type : Observational
Estimated Enrollment : 18 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: FDG-PET/CT in the Diagnosis and Monitoring of Psoriatic Arthritis
Actual Study Start Date : July 2012
Estimated Primary Completion Date : May 2018
Estimated Study Completion Date : May 2018

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Group/Cohort Intervention/treatment
Psoriatic arthritis Radiation: FDG-PET/CT scan
FDG-PET/CT is a type of imaging used currently to look for cancer. We are using it to look at inflammation within the joints.

Primary Outcome Measures :
  1. Primary outcome is inflammation as measured by SUVmax and metabolic volumetric product in the joints and entheses. [ Time Frame: At the discretion of the PI ]

Secondary Outcome Measures :
  1. Correlation of local inflammation in joints and enthesis with systemic inflammatory markers including IL6 and high sensitivity CRP. [ Time Frame: At the discretion of the PI ]

Biospecimen Retention:   Samples With DNA
Plasma, Serum, and Plasma Cells

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with psoriatic arthritis defined by CASPAR criteria and active joint disease.

Inclusion Criteria:

  • Age 18-80,
  • active psoriatic arthritis (joint or enthesis inflammation)

Exclusion Criteria:

  • Diabetes,
  • pregnant,
  • no active PsA

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01654198

United States, Pennsylvania
University of Pennsylvania Division of Rheumatology
Philadelphia, Pennsylvania, United States, 19104
Sponsors and Collaborators
University of Pennsylvania
Principal Investigator: Alexis R Ogdie, MD, MSCE University of Pennsylvania

Responsible Party: University of Pennsylvania
ClinicalTrials.gov Identifier: NCT01654198     History of Changes
Other Study ID Numbers: 815253
First Posted: July 31, 2012    Key Record Dates
Last Update Posted: November 14, 2017
Last Verified: November 2017

Additional relevant MeSH terms:
Arthritis, Psoriatic
Joint Diseases
Musculoskeletal Diseases
Spinal Diseases
Bone Diseases
Skin Diseases, Papulosquamous
Skin Diseases