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Imaging Parameters to Predict Future Vertebral Fracture in Osteoporosis

This study is currently recruiting participants. (see Contacts and Locations)
Verified January 2014 by National Taiwan University Hospital
Information provided by (Responsible Party):
National Taiwan University Hospital Identifier:
First received: July 27, 2012
Last updated: January 23, 2014
Last verified: January 2014
After vertebroplasty, many patients will suffer from 2nd fracture in the vertebral column. With analyzing of the images done right after the 1st vertebroplasty, we can define the parameters from different imaging and they can be predictors of the future fracture.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: to Compare the Efficacy of Parameters From Different Imaging Modality in Predicting the Risk of Future Vertebral Compression Fracture in Osteoporotic Patients.

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • fracture [ Time Frame: 5 years ]
    2nd fracture within 5 years

Estimated Enrollment: 200
Study Start Date: July 2012
Estimated Study Completion Date: December 2017
Estimated Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
Detailed Description:

Vertebroplasty is considered one of the alternatives for the treating of spine compression fracture associated with pain especially for those patients with osteoporosis. However, after vertebroplasty, the compliance of the bone becomes stronger than the adjacent vertebrae that is not treated. So there is always a consideration of future fracture of the adjacent vertebral bodies after vertebroplasty done on certain body. In this study, we try to follow the patients (5 years) to see if the adjacent vertebral bodies are prone to have fracture than the others away from the site of vertebroplasty.Then we try to find out the image biomarkers to predict the future fracture in the vertebral bodies. The should be done with CT scan raw data, analysis with different algorithms.

Inclusion criteria; patients with osteoporosis and receiving vertebroplasty and with secondary fracture occurring in other spine exclusion criteria: No second vertebral body fracture occurred. Primary measurement: the time and location of the 2nd fracture secondary measurement: the imaging biomarkers from CT scan.


Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
all the patients received vertebroplasty treatment between 2005.01-2011.12

Inclusion Criteria:

  • All the patients received vertebroplasty treatment between 2005.01-2011.12 with 2nd fracture in the vertebral column.

Exclusion Criteria:

  • No image available
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01653873

Contact: Hon-man Liu, MD, MBA 886-2-23123456 ext 70329

National Taiwan University Hospital Recruiting
Taipei, Taiwan, 10016
Contact: Hon-Man Liu, MD, MBA    886-2-23123456 ext 70329   
Principal Investigator: Hon-Man Liu, MD, MBA         
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Hon-Man Liu, MD, MBA National Taiwan University Hospital
  More Information

Responsible Party: National Taiwan University Hospital, Chairman Identifier: NCT01653873     History of Changes
Other Study ID Numbers: 201202077RIC
Study First Received: July 27, 2012
Last Updated: January 23, 2014

Keywords provided by National Taiwan University Hospital:
vertebral column

Additional relevant MeSH terms:
Fractures, Bone
Wounds and Injuries
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases processed this record on May 25, 2017