Plasma Cystatin C and Acute Kidney Injury

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2012 by Jinhua Central Hospital.
Recruitment status was  Recruiting
Information provided by (Responsible Party):
Hongying Ni, Jinhua Central Hospital Identifier:
First received: July 26, 2012
Last updated: August 3, 2012
Last verified: August 2012

To evaluate the utility of plasma cystatin C(pCysC) as a predictive and diagnostic marker of acute kidney injury(AKI) in patients undergone cardiopulmonary bypass surgery.

Acute Kidney Injury

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Use of Cystatin C in Predicting AKI in Patients Undergone Cardiopulmonary Bypass Surgery

Further study details as provided by Jinhua Central Hospital:

Estimated Enrollment: 100
Study Start Date: April 2011
Estimated Study Completion Date: May 2013
Estimated Primary Completion Date: May 2013 (Final data collection date for primary outcome measure)
AKI group
patients with AKI after cardiopulmonary bypass surgery
non-AKI group
patients without AKI during study period

Detailed Description:

This is a prospective AKI observational study in patients undergone cardiopulmonary bypass surgery. pCysC and plasma creatine will be measured at entry to ICU.AKI was defined as 50% increase in plasma creatine above baseline.The predictive and diagnostic performance of pCysC will be assessed from area under receiver operator characteristic curve(AUC) and odds ratio(OR).


Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

patients undergone cardiopulmonary bypass surgery


Inclusion Criteria:

  • patients with CPB and admitted to ICU

Exclusion Criteria:

  • patients with the age >80 or <18 years
  • with preexisting renal dysfunction
  Contacts and Locations
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Please refer to this study by its identifier: NCT01652755

Contact: Hongying Ni, MM 86 ext 57982552629

China, Zhejiang
Jinhua central hospital Recruiting
Jinhua, Zhejiang, China, 321000
Contact: Hongying Ni, MM    86 ext 57982552629   
Principal Investigator: Hongying Ni, MM         
Sponsors and Collaborators
Jinhua Central Hospital
Study Chair: Hongying Ni, MM Jinhua municipal central hospital
  More Information

No publications provided

Responsible Party: Hongying Ni, Department vice director, Jinhua Central Hospital Identifier: NCT01652755     History of Changes
Other Study ID Numbers: N-H-Y
Study First Received: July 26, 2012
Last Updated: August 3, 2012
Health Authority: China: Food and Drug Administration

Keywords provided by Jinhua Central Hospital:
cystatin C,acute kidney injury,

Additional relevant MeSH terms:
Acute Kidney Injury
Kidney Diseases
Renal Insufficiency
Urologic Diseases
Cysteine Proteinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Protease Inhibitors processed this record on October 13, 2015