Positive End-expiratory Pressure and Alveolar Recruitment for One Lung Ventilation
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ClinicalTrials.gov Identifier: NCT01652612 |
Recruitment Status
:
Completed
First Posted
: July 30, 2012
Last Update Posted
: July 4, 2013
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
One Lung Ventilation | Other: PEEP | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 99 participants |
Allocation: | Randomized |
Intervention Model: | Single Group Assignment |
Masking: | Double (Participant, Care Provider) |
Primary Purpose: | Prevention |
Official Title: | Effects of Positive End-expiratory Pressure and Alveolar Recruitment on the Oxygenation and Respiratory Mechanics During One-lung Ventilation in the Supine Position |
Study Start Date : | August 2011 |
Actual Primary Completion Date : | February 2013 |
Actual Study Completion Date : | February 2013 |
Arm | Intervention/treatment |
---|---|
No Intervention: Control
zero PEEP
|
|
Experimental: OLV strategy: PEEP
1. apply 8 cm H2O positive end expiratory pressure during one lung ventilation and until the end of surgery
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Other: PEEP
8 cmH2O PEEP throughout the period of OLV and 2nd TLV
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Experimental: OLV strategy: PEEP followed by AR
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Other: PEEP
8 cmH2O PEEP throughout the period of OLV and 2nd TLV
|
- PaO2, number of patients with hypoxia (PaO2< 90mmHg) [ Time Frame: participants will be followed for the duration of anesthesia, an expected average of 3 hours ]blood samplings after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV
- intrapulmonary shunt [ Time Frame: participants will be followed for the duration of anesthesia, an expected average of 3 hours ]blood sampling after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV

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Ages Eligible for Study: | 20 Years to 75 Years (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- ASA I-II
- age: 20-75 years
Exclusion Criteria:
- moderate to severe impaired respiratory function,
- heart failure,
- patients' refusal

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01652612
Korea, Republic of | |
Yong Seon Choi | |
Seoul, Korea, Republic of |
Principal Investigator: | Yongseon Choi | Assistant professor |
Responsible Party: | Yongseon Choi, assistant professor, Yonsei University |
ClinicalTrials.gov Identifier: | NCT01652612 History of Changes |
Other Study ID Numbers: |
4-2011-0301 |
First Posted: | July 30, 2012 Key Record Dates |
Last Update Posted: | July 4, 2013 |
Last Verified: | July 2013 |
Keywords provided by Yongseon Choi, Yonsei University:
positive end expiratory pressure |