We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Positive End-expiratory Pressure and Alveolar Recruitment for One Lung Ventilation

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01652612
First Posted: July 30, 2012
Last Update Posted: July 4, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Yongseon Choi, Yonsei University
  Purpose
Hypoxia frequently develops during one lung ventilation in the supine position.The objective of this article is to study the impact of preemptive alveolar recruitment and subsequent positive end expiratory pressure on arterial oxygenation and lung mechanics during one lung ventilation in the supine position in patients undergoing thoracic surgery .

Condition Intervention
One Lung Ventilation Other: PEEP

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double (Participant, Care Provider)
Primary Purpose: Prevention
Official Title: Effects of Positive End-expiratory Pressure and Alveolar Recruitment on the Oxygenation and Respiratory Mechanics During One-lung Ventilation in the Supine Position

Further study details as provided by Yongseon Choi, Yonsei University:

Primary Outcome Measures:
  • PaO2, number of patients with hypoxia (PaO2< 90mmHg) [ Time Frame: participants will be followed for the duration of anesthesia, an expected average of 3 hours ]
    blood samplings after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV


Secondary Outcome Measures:
  • intrapulmonary shunt [ Time Frame: participants will be followed for the duration of anesthesia, an expected average of 3 hours ]
    blood sampling after induction of anesthesia, 15 and 30 min after OLV, after the 2nd TLV


Enrollment: 99
Study Start Date: August 2011
Study Completion Date: February 2013
Primary Completion Date: February 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
No Intervention: Control
zero PEEP
Experimental: OLV strategy: PEEP
1. apply 8 cm H2O positive end expiratory pressure during one lung ventilation and until the end of surgery
Other: PEEP
8 cmH2O PEEP throughout the period of OLV and 2nd TLV
Experimental: OLV strategy: PEEP followed by AR
  1. alveolar recruitment strategy before one lung ventilation
  2. 8 cmH2O positive end expiratory pressure during one lung ventilation and until the end of surgery
Other: PEEP
8 cmH2O PEEP throughout the period of OLV and 2nd TLV

Detailed Description:
outcome measures: respiratory parameters (Paw, Ppla, Compliance, Vd/Vt)and oxygenation parameters (PaO2, shunt fraction, Pa-AO2)
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   20 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ASA I-II
  • age: 20-75 years

Exclusion Criteria:

  • moderate to severe impaired respiratory function,
  • heart failure,
  • patients' refusal
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01652612


Locations
Korea, Republic of
Yong Seon Choi
Seoul, Korea, Republic of
Sponsors and Collaborators
Yonsei University
Investigators
Principal Investigator: Yongseon Choi Assistant professor
  More Information

Responsible Party: Yongseon Choi, assistant professor, Yonsei University
ClinicalTrials.gov Identifier: NCT01652612     History of Changes
Other Study ID Numbers: 4-2011-0301
First Submitted: December 20, 2011
First Posted: July 30, 2012
Last Update Posted: July 4, 2013
Last Verified: July 2013

Keywords provided by Yongseon Choi, Yonsei University:
positive end expiratory pressure