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Modulation of Cognitive Control by Transcranial Direct Current Stimulation

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01652391
First Posted: July 30, 2012
Last Update Posted: December 31, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Christian Plewnia, MD, University Hospital Tuebingen
  Purpose

Insufficient cognitive control over emotional distracters is characteristic for major depressive disorder (MDD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) is associated with this deficit. In this study the investigators assess the effect of an enhancement of dlPFC activity in MDD patients by anodal transcranial direct current stimulation (tDCS) on cognitive control.

In a double-blinded, balanced randomized, sham-controlled crossover trial the investigators determine the effect of a single-session tDCS to the left dlPFC on cognitive control in MDD patients and healthy controls. To assess the cognitive control the investigators use a delayed response working memory (DWM) task with pictures of varying valence presented during the delay period.


Condition Intervention
Major Depression Device: Transcranial direct current stimulation (tDCS); DC-STIMULATOR (NeuroConn GmbH, Ilmenau, Germany)

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: Modulation of Cognitive Control in Healthy and Depressed Subjects by Transcranial Direct Current Stimulation

Further study details as provided by Christian Plewnia, MD, University Hospital Tuebingen:

Primary Outcome Measures:
  • Correctness of response [ Time Frame: The primary outcome measure is obtained during the intervention (20min tDCS or sham stimulation). ]

Secondary Outcome Measures:
  • Reaction time [ Time Frame: The secondary outcome measure is obtained during the intervention (20min tDCS or sham stimulation). ]

Enrollment: 44
Study Start Date: July 2011
Study Completion Date: December 2012
Primary Completion Date: June 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Anodal transcranial direct current stimulation
Anodal transcranial direct current stimulation (tDCS) 20min, 1mA, F3 (EEG 10/20), reference right M. deltoideus
Device: Transcranial direct current stimulation (tDCS); DC-STIMULATOR (NeuroConn GmbH, Ilmenau, Germany)
Sham Comparator: Sham transcranial direct current stimulation
Sham transcranial direct current stimulation (tDCS) 40s, 1mA, F3 (EEG 10/20), reference right M. deltoideus
Device: Transcranial direct current stimulation (tDCS); DC-STIMULATOR (NeuroConn GmbH, Ilmenau, Germany)

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • age > 18
  • informed consent
  • in the patients group: Major depressive disorder, no antidepressant medication or stability over 1 week

Exclusion Criteria:

  • seizures
  • cardiac pacemaker
  • deep brain stimulation
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01652391


Locations
Germany
Universitiy Hospital Tübingen
Tübingen, Germany
Sponsors and Collaborators
University Hospital Tuebingen
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Christian Plewnia, MD, Professer, University Hospital Tuebingen
ClinicalTrials.gov Identifier: NCT01652391     History of Changes
Other Study ID Numbers: 211/2010BO1_1
First Submitted: July 23, 2012
First Posted: July 30, 2012
Last Update Posted: December 31, 2013
Last Verified: December 2013

Additional relevant MeSH terms:
Depressive Disorder, Major
Depressive Disorder
Mood Disorders
Mental Disorders