Longitudinal Measures of Leptin in Pregnant Women Who Developed Preeclampsia
Background: Obesity in pregnancy is increasing and is a risk factor for metabolic pathology such as preeclampsia. Leptin is an adipokine which has a direct relationship to obesity.
Aim: to measure leptin in lean, obese and diabetic pregnant women at three months intervals throughout their pregnancies.
Methods: Pregnant women were recruited in the 1st trimester of pregnancy, and three groups were formed: a) with pregestational Body Mass Index (BMI) less than 25 kg/m2, b) BMI higher than 25 kg/m2 and c) with Gestational Diabetes Mellitus (GDM). Serum levels of leptin were measured with radioimmunoassay (RIA) technique.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Longitudinal Measures of Leptin in Pregnant Women Who Developed Preeclampsia|
|Study Start Date:||February 2009|
|Study Completion Date:||November 2010|
Pregnant women with overweight/obesity
Pregnant women with gestational diabetes
Pregnant women with normal weight
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01649167
|Principal Investigator:||Verónica Jackeline García Solorio, MSc||Autonomous University of the State of Mexico|
|Study Chair:||Hugo Mendieta Zerón, PhD||Autonomous University of the State of Mexico|