Screening for Preeclampsia With Various Markers in Low-risk Pregnancy Populations
This study has been completed.
First Posted: July 25, 2012
Last Update Posted: July 25, 2012
Information provided by (Responsible Party):
Dong Hyun Cha, CHA University
For the prediction of late-onset preeclampsia (PE) in low risk women, the investigators established a cut-off value for sFlt-1/PlGF ratio and evaluated the combination models of Elecys, second trimester uterine artery (UtA) doppler, and fetoplacental proteins for Down syndrome screening.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Screening Models for Early Detection of Late-onset Preeclampsia With Various Markers in Low-risk Pregnancy Populations|
Resource links provided by NLM:
U.S. FDA Resources
Further study details as provided by Dong Hyun Cha, CHA University:
Primary Outcome Measures:
- identification of patients at risk for late-onset preeclampsia with sFlt-1/PlGF ratio [ Time Frame: at delivery ]
Secondary Outcome Measures:
- identification of patients at risk for late-onset preeclampsia with combined biochemical markers [ Time Frame: at delivery ]
|Study Start Date:||August 2009|
|Study Completion Date:||December 2011|
|Primary Completion Date:||December 2011 (Final data collection date for primary outcome measure)|
A prospective study was carried on in Cha hospital. Serum samples for Down syndrome screening were assayed to estimate pregnancy-associated plasma protein-A (PAPP-A), alpha-fetoprotein , unconjugated estriol, human chorionic gonadotrophin , and inhibin-A. Women screened for Down syndrome were offered UtA Doppler at 20-24 weeks of gestation and then collected serial serum samples for sFlt-1/PlGF ratio at two time points (24-27 and 34-37 weeks' gestation).
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