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Renal Retention of Microbubbles

This study has been completed.
Information provided by (Responsible Party):
Jonathan R. Lindner, MD, Oregon Health and Science University Identifier:
First received: July 19, 2012
Last updated: March 28, 2016
Last verified: March 2016
Flank pain has been reported with ultrasound (US) contrast agents. The purpose of this study is to determine whether there is retention of ultrasound contrast agents in the renal microcirculation, which has been described in mice.

- Study Focus: Renal Retention of Lipid Microbubbles

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Study of Whether There is Renal Retention of Lipid Microbubble Ultrasound Contrast Agents

Further study details as provided by Jonathan R. Lindner, MD, Oregon Health and Science University:

Primary Outcome Measures:
  • Renal Video Intensity Units [ Time Frame: 10 min ]
    Video intensity units in the kidney 10 min after completion of a clinically indicated contrast echocardiography study.

Enrollment: 10
Study Start Date: July 2012
Study Completion Date: October 2012
Primary Completion Date: October 2012 (Final data collection date for primary outcome measure)
Contrast administration
Patients undergoing contrast-enhanced echo.

Detailed Description:
In this study patients undergoing clinically indicated contrast echocardiography will have renal ultrasound performed 10 minutes after completion of contrast infusion to determine the presence and location of renal retention of lipid microbubbles.

Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing contrast echocardoigraphy

Inclusion Criteria:

  • Undergoing clinically indicated contrast echo
  • adequate renal ultrasound images

Exclusion Criteria:

  • chronic inflammatory disease
  • known kidney disease
  • immunomodulatory therapy
  Contacts and Locations
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Please refer to this study by its identifier: NCT01647464

United States, Oregon
Oregon Health & Science University
Portland, Oregon, United States, 97239
Sponsors and Collaborators
Oregon Health and Science University
  More Information

Responsible Party: Jonathan R. Lindner, MD, Professor of Medicine, Oregon Health and Science University Identifier: NCT01647464     History of Changes
Other Study ID Numbers: MBretention
Study First Received: July 19, 2012
Results First Received: October 23, 2015
Last Updated: March 28, 2016 processed this record on August 23, 2017