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Prospective Study on Plasma Pro-endothelin-1 in Predicting Bronchopulmonary Dysplasia

This study has been completed.
University Children's Hospital Basel
Information provided by (Responsible Party):
University of Zurich Identifier:
First received: July 17, 2012
Last updated: May 9, 2016
Last verified: May 2016
Serial quantitative measurements of plasma pro-endothelin-1 concentrations in very preterm infants. Comparing pro-endothelin-1 with established clinical indices of bronchopulmonary dysplasia (BPD). Hypothesis: Pulmonary-vascular remodeling in infants developing BPD is directly related to circulating pro-endothelin-1, which therefore serves as surrogate marker of BPD.

Condition Intervention
Bronchopulmonary Dysplasia
Other: blood sampling

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prospective Study on Plasma Pro-endothelin-1 in Predicting Bronchopulmonary Dysplasia

Resource links provided by NLM:

Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • duration of supplemental oxygen requirement [ Time Frame: 36 weeks postmenstrual age ]
    Bronchopulmonary dysplasia

Secondary Outcome Measures:
  • duration of respiratory pressure support [ Time Frame: during hospitalisation ]
    respiratory pressure support either mechanical and/or nCPAP (days)

Biospecimen Retention:   Samples Without DNA
EDTA plasma

Enrollment: 110
Study Start Date: May 2012
Study Completion Date: December 2013
Primary Completion Date: September 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
VLBW infants Other: blood sampling
blood sampling


Ages Eligible for Study:   up to 4 Months   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
infants born before 32 weeks gestational age

Inclusion criteria:

  • Very preterm infants born before 32 weeks gestational age

Exclusion criteria:

  • Severe fetal malformation, congenital heart defect, inborn syndrome, cardiomyopathy, fetal hydrops
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Please refer to this study by its identifier: NCT01644981

University Hospital Zurich, Division of Neonatology
Zurich, ZH, Switzerland, 8091
Sponsors and Collaborators
University of Zurich
University Children's Hospital Basel
Principal Investigator: Sven Wellmann, MD University Hospital Zurich, Division of Neonatology
  More Information

Responsible Party: University of Zurich Identifier: NCT01644981     History of Changes
Other Study ID Numbers: 1.3 07.10.2011
Study First Received: July 17, 2012
Last Updated: May 9, 2016
Individual Participant Data  
Plan to Share IPD: Undecided

Additional relevant MeSH terms:
Bronchopulmonary Dysplasia
Ventilator-Induced Lung Injury
Lung Injury
Lung Diseases
Respiratory Tract Diseases
Infant, Premature, Diseases
Infant, Newborn, Diseases processed this record on May 23, 2017