Prospective Study on Plasma Pro-endothelin-1 in Predicting Bronchopulmonary Dysplasia
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Serial quantitative measurements of plasma pro-endothelin-1 concentrations in very preterm infants. Comparing pro-endothelin-1 with established clinical indices of bronchopulmonary dysplasia (BPD). Hypothesis: Pulmonary-vascular remodeling in infants developing BPD is directly related to circulating pro-endothelin-1, which therefore serves as surrogate marker of BPD.
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Ages Eligible for Study:
up to 4 Months (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
infants born before 32 weeks gestational age
Very preterm infants born before 32 weeks gestational age