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Cancer Biology of Retinoblastoma

This study has been terminated.
(Logistics)
Sponsor:
ClinicalTrials.gov Identifier:
NCT01642823
First Posted: July 17, 2012
Last Update Posted: March 6, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Stanford University
  Purpose
Many children with the childhood cancer, Retinoblastoma, have surgery to remove the tumor and sometimes the entire eye. The purpose of this study is to collect the extra tissue from patients who undergo tumor removal for laboratory experiments that will help us understand not only what occurs in retinoblastoma cells but also how cells normally function. Some of these studies will include an evaluation of how cells control the way that genes are expressed, how cells "know" to become retinal cells, how cells remain retinal cells, how cells lose their identity as retinal cells, what changes make retinoblastoma cells different from normal retinal cells, and what changes make some retinoblastomas worse than others.

Condition
Retinoblastoma

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Cancer Biology of Retinoblastoma

Resource links provided by NLM:


Further study details as provided by Stanford University:

Primary Outcome Measures:
  • Change in efficiency of reprogramming in cells with "naturally occurring" retinoblastoma mutations [ Time Frame: After appropriate time, e.g., 7, 10, 14 days after reprogramming ]
    Comparison of number of reprogramming events (defined by colony formation assay and normalized for number of cell plated) as well as the time to reprogramming.


Biospecimen Retention:   Samples With DNA
retinoblastoma tumor tissue sample

Enrollment: 8
Study Start Date: July 2012
Study Completion Date: December 2015
Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Groups/Cohorts
retinablastoma tumor tissue

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   up to 5 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Retinoblastoma patients undergoing surgical removal of part or all of their tumor, with or without the remainder of the eye
Criteria

Inclusion Criteria:

  • Patient must have retinoblastoma
  • Patient must be receiving biopsy, partial surgical excision of the tumor, complete excision of the tumor, or enucleation of the eye as part of their standard care.
  • Parental consent

Exclusion Criteria:

  • Diagnosis other than Retinoblastoma
  • No surgical sampling of tumor is planned as part of standard care
  • Parental preference to not participate.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01642823


Locations
United States, California
Stanford University Cancer Institute
Stanford, California, United States, 94305
Guatemala
Unidad Nacional de Oncologia Pediatrica
Guatemala, Guatemala
Sponsors and Collaborators
Stanford University
Investigators
Principal Investigator: Julien Sage Stanford University
  More Information

Responsible Party: Stanford University
ClinicalTrials.gov Identifier: NCT01642823     History of Changes
Other Study ID Numbers: PEDSEYE0002
First Submitted: July 11, 2012
First Posted: July 17, 2012
Last Update Posted: March 6, 2017
Last Verified: March 2017

Keywords provided by Stanford University:
retinoblastoma

Additional relevant MeSH terms:
Retinoblastoma
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Retinal Neoplasms
Eye Neoplasms
Neoplasms by Site
Eye Diseases
Retinal Diseases


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