Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01642706|
Recruitment Status : Unknown
Verified November 2015 by University Hospital, Montpellier.
Recruitment status was: Recruiting
First Posted : July 17, 2012
Last Update Posted : November 20, 2015
|Condition or disease|
|Rheumatoid Arthritis Osteoarthritis Systemic Lupus Erythematosus Sjogren's Syndrome Scleroderma Spondylitis Gout Spinal Disease Chondrocalcinosis|
|Study Type :||Observational|
|Estimated Enrollment :||200 participants|
|Observational Model:||Case Control|
|Official Title:||Regulatory B Cells in Inflammatory Rheumatisms, Systemic Auto-immune Diseases in Adults and Biomarkers of Response to Biologic Treatments|
|Study Start Date :||July 2012|
|Estimated Primary Completion Date :||July 2016|
|Estimated Study Completion Date :||July 2016|
Patients affected by Rheumatoid arthritis.
Subjects affected by mechanical pathologies.
- Assessment of Bregs levels [ Time Frame: 30 months ]The levels of Bregs will be assessed in patients with RA and compared to subjects with mechanical pathologies.
- Change of Bregs levels after therapy [ Time Frame: 30 months ]The levels of Bregs will be assessed in patients who will start a therapy within the framework of their usual follow-up.
Biospecimen Retention: Samples Without DNA
Comparison of Bregs levels
Lymphocytes will be analyzed from :
- circulating blood
- articular serum
- synovial membrane
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01642706
|Contact: Jacques Morel, MD, PhDfirstname.lastname@example.org|
|Contact: Claire Daien, MDemail@example.com|
|Montpellier, France, 34295|
|Contact: Jacques Morel, MD, PhD 0033467338710 firstname.lastname@example.org|
|Contact: Claire Daien, MD 0033673042406 email@example.com|
|Principal Investigator: Jacques Morel, MD, PhD|
|Principal Investigator:||Jacques Morel, MD, PhD||University Hospital, Montpellier|