Myocardial Perfusion and Scarring in Congenital Heart Disease
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|ClinicalTrials.gov Identifier: NCT01639937|
Recruitment Status : Suspended
First Posted : July 13, 2012
Last Update Posted : September 25, 2019
- People with congenital heart disease may develop heart failure earlier that those who do not have the disease. One theory to explain this is that the heart s own blood supply may be different in people with congenital heart disease. Problems with this blood supply can severely damage the heart. This damage can be studied with a heart imaging test called a cardiac magnetic resonance imaging (MRI) scan. Researchers want to use this type of scan to look at the blood supply to the heart in people with congenital heart disease.
- To learn more about the blood supply to the heart in people with congenital heart disease.
- Individuals at least 18 years of age who have heart defects caused by congenital heart disease.
- Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected.
- Participants will have a cardiac MRI scan to look at the blood flow to the heart.
- Participants will also have a heart stress test to measure heart function during exercise.
- Other imaging studies of the heart may be performed to collect more information on heart function.
|Condition or disease|
|Congenital Heart Disease|
|Study Type :||Observational|
|Actual Enrollment :||18 participants|
|Official Title:||Quantitative Myocardial Perfusion, Myocardial Scarring and Their Contribution to Late Clinical Decompensation in Adults With Congenital Heart Disease|
|Study Start Date :||June 22, 2012|
Subjects with palliated congenital heart disease including, but not limited to, d TGA, ccTGA, single ventricles, hypoplastic left heart syndrome and tricuspid atresia will be recruited
- Hypothesize that myocardial ischemia, as detectable by quantitative stress perfusion MRI, will predict systolic and diastolic dysfunction in subjects with single ventricle physiology and systemic right ventricles. [ Time Frame: 5 years ]The specific aim of this study is to understand whether clinical subendocardial perfusion defects contribute to the late decompensation of adult subjects that have single ventricle physiology and adult subjects that have a systemic right ventricle.
- A portion of ventricular systolic or diastolic dysfunction will be predictable based on myocardial fibrosis or scarring related to the underlying pathophysiology of single ventricle physiology & systemic right ventricles or post-surgical... [ Time Frame: 5 years ]
- myocardial scarring/fibrosis will correlate with symptoms, NYHA functional class and BNP. [ Time Frame: 5 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01639937
|United States, District of Columbia|
|Childrens National Medical Center|
|Washington, District of Columbia, United States|
|United States, Maryland|
|Bethesda, Maryland, United States, 20814|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|
|Principal Investigator:||Andrew E Arai, M.D.||National Heart, Lung, and Blood Institute (NHLBI)|