Creation of a Bank of Fibroblast From Patients With Amyotrophic Lateral Sclerosis: Pilot Study (ALSCELL)
Recruitment status was: Recruiting
Patients with ALS will be included in the reference center for ALS in hospital La Pitié Salpêtrière, Paris.
The study proposes to investigate the pathophysiology of ALS by setting up a fibroblast bank for studying molecular, cellular and genetic parameters of the pathology.
iPS (induced pluripotent stem cells) and then differentiated cells will be generated.
The pathophysiology of ALS will be studied on the 3 types of cells (fibroblasts, iPS, differentiated cells).
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Creation of a Bank of Fibroblast From Patients With Amyotrophic Lateral Sclerosis: Pilot Study|
- Success of fibroblast culture, amplification, and freezing pellets [ Time Frame: 2 months ] [ Designated as safety issue: No ]
- Induced pluripotent Stem Cells generation success [ Time Frame: 2 years ] [ Designated as safety issue: No ]
- neurones, motoneurones, glial cells obtention from fibroblasts or iPS [ Time Frame: 2 years ] [ Designated as safety issue: No ]
|Study Start Date:||November 2012|
|Estimated Study Completion Date:||August 2014|
|Estimated Primary Completion Date:||August 2014 (Final data collection date for primary outcome measure)|
Procedure: skin biopsy
biopsy 5mm maximum on healthy skin under local anaesthesia.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01639391
|Centre référent maladies rares SLA|
|Paris, France, 75013|
|Principal Investigator:||Lucette Lacomblez, MD||hôpital La Pitié Salpêtrière, Paris|
|Study Chair:||Delphine Bohl, PhD||Institut Pasteur|