Effects of Secondhand Smoke on Flight Attendant Health (FAMRI)
This is a study on a population of flight attendants who were exposed to occupational secondhand tobacco smoke (SHS). This research will examine associations between flight attendant SHS exposure and development of respiratory illnesses, reproductive problems, and cardiovascular diseases.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Cardiopulmonary Effects of Secondhand Smoke Exposure on Flight Attendants|
- Characterize the long-term effects of SHS on lung and cardiovascular function in pre-ban flight attendants [ Time Frame: 25 minutes ] [ Designated as safety issue: No ]A spirometry test is performed by the Clinical Research Coordinator to establish the lung function of the flight attendant participant and medical assistants from the cardiovascular care clinic administer a 12-lead non-invasive electrocardiogram.
- Clinical Examination [ Time Frame: 30 min ] [ Designated as safety issue: No ]The cardiologist performs a noninvasive assessment of the patient's vascular function, which includes a brief physical examination, blood pressure measurement, pulse, and oxygen level.
- Characterize the long term effects of prolonged flight time and SHS on reproductive health [ Time Frame: 10 minutes ] [ Designated as safety issue: No ]Flight attendants fill out the electronic Exposure Questionnaire prior to their appointments. Part of the Questionnaire is a section on reproductive health. The answers to these survey questions in addition to information gathered and saved in APeX during the clinic visit are used for analysis on reproductive health of flight attendants.
- Characterize the biomarkers of SHS exposure [ Time Frame: 10 minutes ] [ Designated as safety issue: Yes ]A 45 mL blood specimen is drawn from interested patients to be stored in the research lab as well as analyzed in the CLIA approved laboratory. Results of the blood analysis performed in the research labs, such as secondhand smoke biomarkers and advanced lipid biomarkers, will not be shared with the subject. Results of the standard lipid panel (analyzed in a CLIA approved laboratory) will be shared with the subject.
Biospecimen Retention: Samples With DNA
There is an optional blood draw blood portion to the research study. A sample is collected from the interested flight attendant. The majority of the sample is processed and stored in the FAMRI biorepository for future research purposes to identify biomarkers of cardiovascular risk and secondhand smoke. The remainder of the sample is analyzed for the flight attendant. A lipid profile is sent to the flight attendant participant.
|Study Start Date:||January 2005|
|Estimated Study Completion Date:||August 2017|
|Estimated Primary Completion Date:||August 2017 (Final data collection date for primary outcome measure)|
The main hypothesis of this study is that exposure to the secondhand tobacco smoke (SHS) in the confined workspace of commercial aircraft prior to the ban of cigarette smoking is responsible for long-term damage on the health of nonsmoking flight attendants. We will compare the data collected from our pre-ban flight attendant participants to age-matched, nonsmoking controls from the NHANES database. The results of our study should permit us to determine if SHS exposure is the cause of long-term increased cardiovascular morbidity and risk, as well as increased susceptibility to respiratory illnesses.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01639235
|Contact: Victoria Hayes||415-412-0872||Victoria.Hayes@ucsf.edu|
|Contact: Paula Tarr||415-502-2345||Paula.Tarr@ucsf.edu|
|United States, California|
|University of California, San Francisco (UCSF)||Recruiting|
|San Francisco, California, United States, 94143|
|Contact: Paula Tarr 415-502-2345 Paula.Tarr@ucsf.edu|
|Principal Investigator: Rita Redberg, MD|
|Sub-Investigator: Eveline Stock, MD|
|Principal Investigator:||Rita Redberg, MD||University of California, San Francisco|