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Effects of Humidified Ventilation on Arterial Oxygenation and Respiratory Mechanics During One Lung Ventilation

This study has been completed.
Information provided by (Responsible Party):
Yonsei University Identifier:
First received: July 5, 2012
Last updated: July 9, 2012
Last verified: July 2012
A continuous loss of moisture and heat occurs during mechanical ventilation and prediposes patients to airway damage. Vaporizing humidifier has known to be advantages of improvement of oxygenation and protection of airway damage. However, there is a lack of study about the effect of humidified ventilation on oxygenation and respiratory mechanics during one-lung ventilation. We therefore invesgate that the effect of humidified ventilation on oxygenation and respiratory mechanics during one-lung ventilation .

Condition Intervention
Lung Cancer
Procedure: Vaporizing humidifier

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Double Blind (Participant, Outcomes Assessor)

Resource links provided by NLM:

Further study details as provided by Yonsei University:

Primary Outcome Measures:
  • arterial oxygenation [ Time Frame: T1(10min before one-lung ventilation),T2(30min after one-lung ventilation),T3(60min), T4(10min after two lung ventilation) ]
    T1,T2,T3,T4: all measurement in lateral position, T1-arterial oxygenation(PaO2), T2-arterial oxygenation(PaO2),T3-arterial oxygenation(PaO2),T4-arterial oxygenation(PaO2)

Secondary Outcome Measures:
  • Respiratory dynamic parameters [ Time Frame: T1,T2,T3,T4 (same as 'primary outcome measure') ]
    T1,T2,T3,T4: T1-respiratory dynamic parameters, T2-respiratory dynamic parameters, T3-respiratory dynamic parameters, T4-respiratory dynamic parameters

Enrollment: 60
Study Start Date: March 2011
Study Completion Date: April 2012
Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Vaporizing humidifier
Vaporizing humidifier applying during one-lung ventilation
Procedure: Vaporizing humidifier
Vaporizing humidifier applying during one-lung ventilation


Ages Eligible for Study:   30 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • ASA physical status class I,II
  • Unilateral lung lobectomy
  • Use of one-lung ventilation

Exclusion Criteria:

  • COPD
  • CAOD
  • Unstable cardiovascular status
  • Peak inspiratory pressure > 30 mmHg
  Contacts and Locations
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Please refer to this study by its identifier: NCT01636973

Korea, Republic of
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
Seoul, Korea, Republic of, 120-752
Sponsors and Collaborators
Yonsei University
Study Chair: Young Jun Oh, M.D.,PhD. Yonsei University
  More Information

Responsible Party: Yonsei University Identifier: NCT01636973     History of Changes
Other Study ID Numbers: 1-2011-0027
Study First Received: July 5, 2012
Last Updated: July 9, 2012

Keywords provided by Yonsei University:
Lung cancer processed this record on April 26, 2017