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Effects of Humidified Ventilation on Arterial Oxygenation and Respiratory Mechanics During One Lung Ventilation

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01636973
First Posted: July 10, 2012
Last Update Posted: July 10, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Yonsei University
  Purpose
A continuous loss of moisture and heat occurs during mechanical ventilation and prediposes patients to airway damage. Vaporizing humidifier has known to be advantages of improvement of oxygenation and protection of airway damage. However, there is a lack of study about the effect of humidified ventilation on oxygenation and respiratory mechanics during one-lung ventilation. We therefore invesgate that the effect of humidified ventilation on oxygenation and respiratory mechanics during one-lung ventilation .

Condition Intervention
Lung Cancer Procedure: Vaporizing humidifier

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Double (Participant, Outcomes Assessor)

Resource links provided by NLM:


Further study details as provided by Yonsei University:

Primary Outcome Measures:
  • arterial oxygenation [ Time Frame: T1(10min before one-lung ventilation),T2(30min after one-lung ventilation),T3(60min), T4(10min after two lung ventilation) ]
    T1,T2,T3,T4: all measurement in lateral position, T1-arterial oxygenation(PaO2), T2-arterial oxygenation(PaO2),T3-arterial oxygenation(PaO2),T4-arterial oxygenation(PaO2)


Secondary Outcome Measures:
  • Respiratory dynamic parameters [ Time Frame: T1,T2,T3,T4 (same as 'primary outcome measure') ]
    T1,T2,T3,T4: T1-respiratory dynamic parameters, T2-respiratory dynamic parameters, T3-respiratory dynamic parameters, T4-respiratory dynamic parameters


Enrollment: 60
Study Start Date: March 2011
Study Completion Date: April 2012
Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Vaporizing humidifier
Vaporizing humidifier applying during one-lung ventilation
Procedure: Vaporizing humidifier
Vaporizing humidifier applying during one-lung ventilation

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ASA physical status class I,II
  • Unilateral lung lobectomy
  • Use of one-lung ventilation

Exclusion Criteria:

  • COPD
  • CAOD
  • Unstable cardiovascular status
  • Peak inspiratory pressure > 30 mmHg
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01636973


Locations
Korea, Republic of
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
Seoul, Korea, Republic of, 120-752
Sponsors and Collaborators
Yonsei University
Investigators
Study Chair: Young Jun Oh, M.D.,PhD. Yonsei University
  More Information

Responsible Party: Yonsei University
ClinicalTrials.gov Identifier: NCT01636973     History of Changes
Other Study ID Numbers: 1-2011-0027
First Submitted: July 5, 2012
First Posted: July 10, 2012
Last Update Posted: July 10, 2012
Last Verified: July 2012

Keywords provided by Yonsei University:
Lung cancer