Plasma Concentrations of Bupivacaine After Peri-articular Injection in Total Knee Arthroplasty
This study has been completed.
Information provided by (Responsible Party):
Saowaphak Lapmahapaisan, Mahidol University
First received: July 5, 2012
Last updated: July 25, 2014
Last verified: July 2014
Patients with knee arthroplasty usually performed under spinal anesthesia with a single-shot femoral nerve block and periarticular block, so we would like to know the plasma concentration of bupivacaine in these patients.
Serum Bupivacaine Level
Total Knee Arthroplasty
||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
||Plasma Concentrations of Bupivacaine After Spinal Anesthesia With Single Shot Femoral Nerve Block and Peri-articular Injection in Total Knee Arthroplasty
Primary Outcome Measures:
- plasma concentration of bupivacaine after spinal anesthesia with single-shot femoral nerve block and periarticular block [ Time Frame: 2 hours ]
Secondary Outcome Measures:
- bupivacaine toxicity [ Time Frame: 24 hr ]
| Study Start Date:
| Study Completion Date:
| Primary Completion Date:
||July 2014 (Final data collection date for primary outcome measure)
20 ml of 0.5% bupivacaine for single-shot femoral nerve block will be done at the beginning then another 20 ml of 0.5% bupivacaine for periarticular block will be performed at the end of operation.
Blood sample will be drawn at 60 min after femoral nerve block and before periarticular block, 15, 30, 45, 60 min after periarticular block.
|Ages Eligible for Study:
||30 Years to 70 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- age of 30-70 yr
- ASA I-II
- patient undergo total knee arthroplasty under spinal block and single shot femoral nerve block and periarticular block
- patient's refusal
- allergic to bupivacaine
- body weight less than 50 kg
- liver disease
- heart disease
- infection at both groin
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01636869
|Faculty of Medicine, Siriraj Hospital, Mahidol University
|Bangkok, Thailand, 10700 |
||Saowaphak Lapmahapaisan, instructor, Mahidol University
History of Changes
|Other Study ID Numbers:
|Study First Received:
||July 5, 2012
||July 25, 2014
Keywords provided by Mahidol University:
total knee arthroplasty
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on January 19, 2017
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents