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Effectiveness of Internet-based Depression Treatment (EVIDENT)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2015 by Philipp Klein, University of Luebeck.
Recruitment status was:  Active, not recruiting
Information provided by (Responsible Party):
Philipp Klein, University of Luebeck Identifier:
First received: July 5, 2012
Last updated: May 26, 2015
Last verified: May 2015
Care for people suffering from depressive symptoms should be given in a step-wise approach. One first step can be the provision of self-help material. Online self-help is an innovative way of providing self-help. The investigators want to study the effect of an interactive online self-help-program (Deprexis) in the treatment of mild to moderate depressive symptoms. Participants will be randomised to either twelve weeks of online-self help or a waiting-list control. Symptoms of depression and other aspects will be assessed over a one year period. Thereafter the controls will also receive online-self help. The investigators hypothesise that online self-help is superior to the control condition in alleviating depressive symptoms and preventing full blown depression.

Condition Intervention
Mild to Moderate Depressive Symptoms Behavioral: Deprexis

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment

Further study details as provided by Philipp Klein, University of Luebeck:

Primary Outcome Measures:
  • Personal Health Questionnaire (PHQ-9) [ Time Frame: 12 wks ]

Secondary Outcome Measures:
  • Hamilton Rating Scale for Depression (HRSD) [ Time Frame: 12 wks, 6 mths, 12 mths ]
  • Quick Inventory of Depressive Symptoms (QIDS) [ Time Frame: 12 wks, 6 mths, 12 mths ]
  • Personal Health Questionnaire (PHQ-9) [ Time Frame: 6 mths, 12 mths ]

Estimated Enrollment: 1000
Study Start Date: July 2012
Estimated Study Completion Date: February 2017
Primary Completion Date: February 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Deprexis
Online self-help with and without e-mail-support
Behavioral: Deprexis
Online self-help with and without e-mail-support
No Intervention: Control

Detailed Description:
This study is supported by the German Ministry of Health (BMG) and is a collaborative project of Universität Bern (PD Dr. Thomas Berger), Charité Berlin (PD Dr. Matthias Rose), Universität Bielefeld (Prof. Dr. Wolfgang Greiner), Universität Hamburg (Prof. Dr. Steffen Moritz, Prof. Dr. Bernd Löwe), GAIA AG Hamburg (Dr. Björn Meyer), Universität Tübingen (Prof. Dr. Martin Hautzinger) and Universität Trier (Prof. Dr. Wolfgang Lutz).

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • PHQ>4 and <15

Exclusion Criteria:

  • acute suicidality
  • psychotic d/o, bipolar d/o or other severe psychiatric d/o
  Contacts and Locations
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Please refer to this study by its identifier: NCT01636752

Charité Berlin
Berlin, Germany
Universität Bielefeld
Bielefeld, Germany
Universität Hamburg
Hamburg, Germany
Universität Lübeck
Lübeck, Germany
Sponsors and Collaborators
University of Luebeck
  More Information

Responsible Party: Philipp Klein, Coordinating Investigator, University of Luebeck Identifier: NCT01636752     History of Changes
Other Study ID Numbers: EVIDENT Trial
Study First Received: July 5, 2012
Last Updated: May 26, 2015

Additional relevant MeSH terms:
Behavioral Symptoms processed this record on July 21, 2017