ClinicalTrials.gov
ClinicalTrials.gov Menu

Reliability of Measuring Conditioned Pain Modulation With the Nociceptive Withdrawal Reflex

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01636440
Recruitment Status : Completed
First Posted : July 10, 2012
Last Update Posted : January 21, 2013
Sponsor:
Collaborator:
Aalborg University
Information provided by (Responsible Party):
University Hospital Inselspital, Berne

Brief Summary:
Conditioned pain modulation is the ability of the spine to describe changes in pain perception, if two different painful stimulations take place. The reliability of the conditioned pain modulation has not been studied, the instruments used to measure the conditioned pain modulation are sparse and have proven difficult to use in a well reproductible way. This study is using an existing pain test, relying on the reflex in a muscle after a painful electrical stimulation. We will test 34 healthy volunteers in order to test the reliability of the conditioned pain modulation with the nociceptive withdrawal reflex combined to a ice water test.

Condition or disease Intervention/treatment Phase
Healthy Volunteers Device: Conditioned Pain Modulation Not Applicable

  Show Detailed Description

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 39 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Reliability of Measuring Conditioned Pain Modulation With the Nociceptive Withdrawal Reflex
Study Start Date : June 2012
Actual Primary Completion Date : August 2012
Actual Study Completion Date : August 2012

Arm Intervention/treatment
Reliability
The same testing procedure is repeated after a delay of 7 days to test the reliability of the measure
Device: Conditioned Pain Modulation
Measure of the conditioned pain modulation with the nociceptive withdrawal reflex and ice water stimulation

Device: Conditioned Pain Modulation
Suprathreshold electrical stimulation with 1.5 times the mean electrical pain detection threshold




Primary Outcome Measures :
  1. Reliability of CPM with the nociceptive withdrawal reflex [ Time Frame: two minutes after the cold pressor test ]

Secondary Outcome Measures :
  1. Reliability of CPM with electric pain detection threshold [ Time Frame: two minutes after the cold pressor test ]
  2. Reliability of CPM with suprathreshold electrical pain detection threshold stimulation [ Time Frame: two minutes after the cold pressor test ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male Gender
  • Age 18-65
  • Signed Informed Consent

Exclusion Criteria

  • Signs or suspicion of neurologic dysfunction or disease
  • Ongoing treatment with any drug known to influence pain modulation: any analgesic, antidepressant, anticonvulsant or benzodiazepine
  • Intake of any analgesic drug during the 48h preceding the experiment.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01636440


Locations
Switzerland
Dep. of Anesthesiology and Pain Medicine, Bern University Hospital
Bern, Switzerland, 3010
Sponsors and Collaborators
University Hospital Inselspital, Berne
Aalborg University
Investigators
Study Director: Michele Curatolo, MD University Hosptial Bern

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: University Hospital Inselspital, Berne
ClinicalTrials.gov Identifier: NCT01636440     History of Changes
Other Study ID Numbers: 070/12
SNF: SPUM 33CM30_124117
First Posted: July 10, 2012    Key Record Dates
Last Update Posted: January 21, 2013
Last Verified: January 2013

Keywords provided by University Hospital Inselspital, Berne:
Conditioned Pain Modulation