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Comparison of Muscle Atrophy After Direct Anterior & Posterior Total Hip Arthroplasty

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Jose Rodriguez, MD, Northwell Health Identifier:
First received: June 29, 2012
Last updated: December 14, 2016
Last verified: December 2016

This project is designed to use MRI to evaluate pre- and post-arthroplasty hips; the specific aims of this project are three-fold. First, the investigators intend to compare the amount of muscle atrophy and tendon damage that occurs around the hip between two commonly-used operative approaches: the direct-anterior approach and the posterior approach. Second, the investigators aim to provide baseline data on the amount of muscle atrophy and tendon damage that should reasonably be expected to occur with both of these approaches. Third, the investigators will document the degree of recovery of the periprosthetic soft tissues post-surgery in both patient groups.

The investigators first hypothesis is that the posterior approach will demonstrate significantly more damage to the abductors, piriformis, and short external rotators than the direct anterior approach, which will demonstrate minimal soft tissue damage. The investigators second hypothesis is that both surgical approaches will cause some degree of baseline muscle damage and atrophy, in a predictable pattern. The investigators third hypothesis is that each of the surgical approaches inherently cause some degree of soft tissue damage, and that the periprosthetic soft tissues that are incised during the surgical exposure will recover in a predictable pattern which is consistent but unique within each group

Osteoarthritis, Hip

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: The Influence of Operative Approach on Muscle Atrophy After Total Hip Arthroplasty: A Comparison of Anterior and Posterior Approaches

Further study details as provided by Jose Rodriguez, MD, Northwell Health:

Primary Outcome Measures:
  • Change from baseline in muscle volume at 6 weeks [ Time Frame: 6 weeks after surgery ]
    Muscle volume will be recorded in MRI images with specialized software (external rotators,tensor fascia lata, rectus femoris,gluteus medius and minimus)

  • Change from baseline in muscle volume at 6 months [ Time Frame: 6 months after surgery ]

Secondary Outcome Measures:
  • Change in Fatty atrophy of muscles from baseline at 6weeks [ Time Frame: 6 weeks after surgery ]
    Qualitative assessment of fatty atrophy

  • tendon damage [ Time Frame: 6 weeks after surgery ]
    Qualitative assessment of tendon damage on MRI

  • Change in fatty atrophy of muscles from baseline at 6 months [ Time Frame: 6 months after surgery ]
  • Tendon damage [ Time Frame: 6 months after surgery ]

Enrollment: 19
Study Start Date: May 2012
Estimated Study Completion Date: July 2018
Estimated Primary Completion Date: July 2018 (Final data collection date for primary outcome measure)
Direct Anterior Approach
Posterior Approach


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing Total Hip arthroplasty by one of the two fellowship trained arthroplasty surgeons.

Inclusion Criteria:

  1. Patients undergoing elective, primary total hip arthroplasty
  2. Use of Cementless Total Hip components
  3. Preoperative diagnosis of degenerative joint disease secondary to osteoarthritis

Exclusion Criteria:

  1. Prior surgery on the affected hip
  2. No implanted medical devices or metallic debris in the patient which will preclude use of MRI
  3. patients must be able to participate in standard post-arthroplasty rehabilitation protocols.
  Contacts and Locations
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Please refer to this study by its identifier: NCT01636375

United States, New York
NorthShoreLIJ/LenoxHill Hospital
New York, New York, United States, 10075
Sponsors and Collaborators
Northwell Health
Principal Investigator: Jose A Rodriguez, MD NorthShoreLIJ/LenoxHill Hospital
  More Information

Responsible Party: Jose Rodriguez, MD, MD, Director, Center For Joint Preservation & Reconstruction,NorthShoreLIJ/LenoxHill Hospital, Northwell Health Identifier: NCT01636375     History of Changes
Other Study ID Numbers: MRI DAA/PA
Study First Received: June 29, 2012
Last Updated: December 14, 2016

Additional relevant MeSH terms:
Osteoarthritis, Hip
Muscular Atrophy
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Pathological Conditions, Anatomical
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on August 18, 2017