Vitamin D and Critically Ill Patients
The higher rate of vitamin D deficiency is spotted among patients being hospitalized or in critical condition. Especially, vitamin D level below normal prolongs hospital stay and increases incidence of adverse prognosis and pushing up mortality of a number of diseases. However, it is remain unclear the relationship between vitamin D levels and critically ill, especially infection or sepsis. In this study, the investigators evaluate the significance of vitamin D for diagnosis and other relevant assessments of ICU cases, including vitamin D's relevance to sepsis, as well as its value in severity and prognosis assessment, high-performance liquid chromatography and tandem mass spectrometry was used to detect the quantification of the total 25(OH)D in serum of critically ill patients. The investigators speculate that measurement of vitamin D could be taken as an indicator for diagnosis and assessment in critically ill patients.
Systemic Inflammatory Response Syndrome
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Vitamin D Levels and Risk of Infection, Assessment for Disease Severity, and Predictor of Mortality in the Chinese Intensive Care Units: a Prospective Cohort Study|
- Patients Outcome [ Time Frame: 28 days ] [ Designated as safety issue: No ]The survival time of patients more than 28 days is defined as survival. The survival time of patients less than 28 days is defined as death.
- Patients Outcome [ Time Frame: 90 days ] [ Designated as safety issue: No ]The survival time of patients more than 90 days is defined as survival. The survival time of patients less than 90 days is defined as death.
|Study Start Date:||October 2011|
|Study Completion Date:||December 2011|
|Primary Completion Date:||December 2011 (Final data collection date for primary outcome measure)|
ICU sepsis group
The ICU sepsis group consisting of 105 critically-ill cases diagnosed with sepsis upon admission and sampled within the first 24h of their ICU stay.
ICU control group
the ICU control group including 51 critically-ill cases in whom sepsis was clinically excluded and from whom samples were taken upon admission.
healthy control group
the healthy control group composed of 50 healthy control outpatients. For the healthy control outpatients, possibilities of acute or past chronic diseases were excluded. Moreover, we made sure that the healthy control subjects had not been hospitalized or taken vitamin-based substitutive drugs in the last 12 months, and proved normal in physical checkups and lab examinations.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01636232
|Chinese PLA General Hospital|
|Beijing, China, 100853|
|Study Director:||Lixin Xie, MD||Department Of Respiratory Diseases, Chinese PLA General Hospital|