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Coronary CT Angiography to Predict Vascular Events In Noncardiac Surgery patIents cOhort evaluatioN (CTA -VISION) Study (CTA-VISION)

This study has been completed.
Information provided by (Responsible Party):
Philip Devereaux, McMaster University Identifier:
First received: July 4, 2012
Last updated: April 27, 2015
Last verified: April 2015
Worldwide 200 million adults annually undergo major noncardiac surgery and 5 million of these patients will suffer a major vascular complication. Despite the magnitude of this problem our capacity to predict these events is limited. Although perioperative myocardial infarction (MI) is the most common major perioperative cardiac complication, little is known about its pathophysiology. Coronary computed tomography angiography (CTA) is a potential non-invasive method for the detection of coronary artery disease and cardiac risk stratification in the non-operative setting; however, the value of this test to enhance risk prediction among patients scheduled for noncardiac surgery is unknown. This study is an international prospective cohort study to determine among patients with, or at risk of, atherosclerotic disease who are undergoing noncardiac surgery: 1) if preoperative coronary CTA has additional predictive value for the occurrence of major perioperative cardiac events and 2) the underlying coronary anatomy associated with perioperative MIs.

Condition Intervention
Cardiovascular Disease Other: Coronary CT Angiogram

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Coronary CT Angiography to Predict Vascular Events In Noncardiac Surgery patIents cOhort evaluatioN (CTA -VISION) Study

Further study details as provided by Philip Devereaux, McMaster University:

Primary Outcome Measures:
  • Perioperative MI [ Time Frame: 30-days post-operative ]

Secondary Outcome Measures:
  • Perioperative Cardiovascular Event [ Time Frame: 30-days post-operative ]

Enrollment: 987
Study Start Date: May 2007
Study Completion Date: November 2014
Primary Completion Date: November 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Non-cardiac surgical patients
>= 45 years old, undergoing non-cardiac surgery requiring regional or general anaesthetic and an overnight stay with cardiac risk factors
Other: Coronary CT Angiogram
pre-operative coronary CTA


Ages Eligible for Study:   45 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
International non cardiac surgical patients

Inclusion Criteria:

  • age >=45 years
  • undergoing non cardiac surgery requiring an overnight stay and general or regional anaesthetic
  • at least one of:

    1. Coronary Artery Disease (CAD)
    2. Peripheral Vascular Disease (PVD)
    3. History of Stroke
    4. History of Congestive Heart Failure (CHF)
    5. Combination of at least 3 of:
  • age >= 70 years
  • history of treatment for hypertension
  • history of treatment for dyslipidemia
  • smoking in last 2 years
  • diabetic and currently taking insulin or oral diabetic drugs
  • history of Transient Ischemic Attack (TIA)

Exclusion Criteria:

  • contraindications to CTA
  Contacts and Locations
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Please refer to this study by its identifier: NCT01635309

Canada, Ontario
Juravinski Hospital
Hamilton, Ontario, Canada, L8V5C2
Sponsors and Collaborators
Canadian Institutes of Health Research (CIHR)
  More Information

Responsible Party: Philip Devereaux, Principal Investigator, McMaster University Identifier: NCT01635309     History of Changes
Other Study ID Numbers: CTA-VISION
Study First Received: July 4, 2012
Last Updated: April 27, 2015

Additional relevant MeSH terms:
Cardiovascular Diseases processed this record on September 21, 2017