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Pediatric Radio Frequency Coils Generic

This study is currently recruiting participants. (see Contacts and Locations)
Verified August 2016 by Children's Hospital Medical Center, Cincinnati
Information provided by (Responsible Party):
Children's Hospital Medical Center, Cincinnati Identifier:
First received: June 21, 2012
Last updated: August 31, 2016
Last verified: August 2016
The purpose of this study is to evaluate and optimize advances in radio frequency (RF) coil magnetic resonance imaging (MRI) technology at Cincinnati Children's Hospital Medical Center (CCHMC).

Condition Phase
Duchenne Muscular Dystrophy
Musculoskeletal Abnormalities
Phase 1
Phase 2

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Pediatric Radio Frequency Coil Development on Clinical and Research MR Scanners

Resource links provided by NLM:

Further study details as provided by Children's Hospital Medical Center, Cincinnati:

Primary Outcome Measures:
  • Number of participants with adverse events as measured by heating and comfort participant response [ Time Frame: Day 1 ]

Secondary Outcome Measures:
  • MRI Image Quality [ Time Frame: 2 Weeks Post MRI Scan ]

Estimated Enrollment: 75
Study Start Date: July 2012
Estimated Study Completion Date: June 2017
Estimated Primary Completion Date: June 2017 (Final data collection date for primary outcome measure)
Advances in Radio Frequency for MRI
advances in radio frequency (RF) coil magnetic resonance imaging (MRI)

Detailed Description:

Pediatric Magnetic resonance (MR) imaging techniques have been limited by the unavailability of specialized radio-frequency (RF) coils for pediatric imaging. Typically, MR coils are designed for general purpose adult imaging and lack the mechanical design, flexibility and high channel count needed for pediatric imaging. Furthermore, pediatric patients are often positioned decubitus or prone rather than supine. This makes coil positioning even more challenging and often results in images with low SNR and poor image quality. Many coils used in clinical practice have fixed dimensions that do not fit within the realm of "one-size fits all," especially for the huge variation found in the pediatric patient population.

MRI coil development and optimization is performed by MR manufacturers and in research laboratories across the world including the Imaging Research Center (IRC) of Cincinnati Children's Hospital and Medical Center (CCHMC). Coil development and refinement involves evaluating the new coils on inert phantoms and then imaging examinations performed on healthy participants and patients. The focus of this study protocol is to evaluate the design and performance of investigational coils on patients and healthy participants.


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy participants will be recruited by word-of-mouth, generally from within CCHMC.The healthy participants could include children of faculty or staff members of CCHMC.Because the healthy participants could include children of faculty or staff members, recruitment will be consistent with CCHMC Research Policy.Patients will be recruited at the time of their scheduled clinical scan.We are only using these participants to evaluate the safety and feasibility of the use of the new coils in our patient population.For this reason, we will not focus on the demographics of the participants.However, we will attempt to obtain a broad anatomic size range to match that of the patient population for which the coils were developed.

Inclusion Criteria:

Healthy participants:

  • Male or Female
  • Thermally stable
  • Any age

Clinical patients:

  • Male or Female
  • Thermally stable
  • any age

Exclusion Criteria:

Healthy participants & Clinical patients

  • Female participants who are pregnant or lactating
  • Subjects iwth standard contraindications to MRI
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01633866

United States, Ohio
Cincinnati Children's Recruiting
Cincinnati, Ohio, United States, 45229
Contact: Kansie E Somers, M.A.    513-636-9403   
Sponsors and Collaborators
Children's Hospital Medical Center, Cincinnati
Principal Investigator: Charles Dumoulin, PhD Children's Hospital Medical Center, Cincinnati
  More Information

Responsible Party: Children's Hospital Medical Center, Cincinnati Identifier: NCT01633866     History of Changes
Other Study ID Numbers: 2012-1041
Study First Received: June 21, 2012
Last Updated: August 31, 2016

Keywords provided by Children's Hospital Medical Center, Cincinnati:
Magnetic Resonance Imaging

Additional relevant MeSH terms:
Muscular Disorders, Atrophic
Muscular Diseases
Congenital Abnormalities
Muscular Dystrophies
Muscular Dystrophy, Duchenne
Musculoskeletal Abnormalities
Musculoskeletal Diseases
Neuromuscular Diseases
Nervous System Diseases
Genetic Diseases, Inborn
Genetic Diseases, X-Linked processed this record on May 25, 2017