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Zinc Absorption From Biofortified Rice
This study has been completed.
Sponsor:
Swiss Federal Institute of Technology
Collaborator:
University of Zurich
Information provided by (Responsible Party):
Prof. Michael B. Zimmermann, Swiss Federal Institute of Technology
ClinicalTrials.gov Identifier:
NCT01633450
First received: June 29, 2012
Last updated: June 6, 2013
Last verified: June 2013
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Purpose
One of the newest strategies to combat micronutrient deficiencies is the biofortification of staple foods, where higher levels of minerals are obtained through breeding of staple crops. The aim of this study is to evaluate zinc absorption from a rice biofortified with zinc when compared with a control rice fortified with zinc just before consumption.
| Condition | Intervention |
|---|---|
| Healthy | Other: Zinc biofortified rice Other: Rice extrinsically fortified with zinc |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Crossover Assignment Masking: Single Blind (Participant) |
| Official Title: | Bioavailability of Zinc From Rice Biofortified With 70Zn and Rice Extrinsically Labeled With 70Zn in Young Adults: a Randomized, Single-blind Study |
Further study details as provided by Prof. Michael B. Zimmermann, Swiss Federal Institute of Technology:
Primary Outcome Measures:
- Fractional absorption of zinc [ Time Frame: 33 days ]Fractional absorption of zinc is estimated by using the double isotope tracer ratio technique by administering 67Zn as oral and 70Zn as intravenous stable isotopes.The urinary enrichment with both isotopes is measured in a spot urine sample by inductively coupled plasma mass spectrometry.
| Enrollment: | 16 |
| Study Start Date: | June 2012 |
| Study Completion Date: | October 2012 |
| Primary Completion Date: | August 2012 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
| Experimental: Zinc biofortified rice |
Other: Zinc biofortified rice
1.12 mg zinc per meal
|
| Active Comparator: Rice extrinsically fortified with zinc |
Other: Rice extrinsically fortified with zinc
1.12 mg zinc per meal
|
Eligibility| Ages Eligible for Study: | 18 Years to 45 Years (Adult) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- Male or female of 18 to 45 years old
- Body Mass Index in the range of 19 to 25
- No mineral and vitamin supplements two weeks prior to the study and during the whole duration of the study
Exclusion Criteria:
- Any metabolic, gastrointestinal or chronic disease (according to the subjects own statement)
- Long-term medication during the whole study (except for contraceptives)
- Pregnancy
- Lactation
- Intention to become pregnant during the course of the study
- Lack of safe contraception
- Consumption of mineral and vitamin supplements within 2 weeks prior to 1st - Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01633450
Please refer to this study by its ClinicalTrials.gov identifier: NCT01633450
Locations
| Switzerland | |
| ETH Zurich | |
| Zurich, Switzerland | |
Sponsors and Collaborators
Swiss Federal Institute of Technology
University of Zurich
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| Responsible Party: | Prof. Michael B. Zimmermann, Prof, Swiss Federal Institute of Technology |
| ClinicalTrials.gov Identifier: | NCT01633450 History of Changes |
| Other Study ID Numbers: |
HNL/CTC12-Reis |
| Study First Received: | June 29, 2012 |
| Last Updated: | June 6, 2013 |
Additional relevant MeSH terms:
|
Zinc Trace Elements Micronutrients Growth Substances Physiological Effects of Drugs |
ClinicalTrials.gov processed this record on June 26, 2017