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Performance-based Reinforcement to Enhance Cognitive Remediation Therapy

This study has been completed.
Information provided by (Responsible Party):
Yale University Identifier:
First received: June 27, 2012
Last updated: July 16, 2015
Last verified: July 2015
The purpose of this study is to investigate whether monetary reinforcement for performance will enhance the effects of cognitive remediation therapy for substance users seeking treatment at an outpatient facility.

Condition Intervention Phase
Substance-Related Disorders
Mental Disorders
Behavioral: Cognitive Remediation Therapy - Standard
Behavioral: Cognitive Remediation Therapy plus Contingency Management
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Pilot Study of Performance-based Reinforcement to Enhance Cognitive Remediation Therapy for Substance Users

Further study details as provided by Yale University:

Primary Outcome Measures:
  • Improvement in performance scores on computerized cognitive remediation tasks [ Time Frame: 4 weeks ]
    Performance scores on various computerized cognitive remediation tasks will be measured repeatedly during the 4 week study. These scores include "time to completion", "number of errors", "number of words correctly recalled", and "percentage of task completed"

Secondary Outcome Measures:
  • Improved cognitive function on neuropsychological tests [ Time Frame: 4 weeks ]
    Change in cognitive function between baseline and post-treatment will be measured by performance on neuropsychological tests, such as Trail Making Test A & B, Wisconsin Card Sort Test, Digit Symbol Test from WAIS-IV, and the Continuous Performance Test-II (CPT-II).

Enrollment: 40
Study Start Date: September 2012
Study Completion Date: December 2014
Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: CRT-S
Cognitive Remediation Therapy - Standard
Behavioral: Cognitive Remediation Therapy - Standard
Computerized cognitive remediation therapy provided three times per week for four weeks
Experimental: CRT-CM
Cognitive Remediation Therapy plus Contingency Management
Behavioral: Cognitive Remediation Therapy plus Contingency Management
Standard cognitive remediation therapy plus monetary incentives based on performance provided three times per week for four weeks.

Detailed Description:
Forty individuals seeking treatment for an alcohol or cocaine use disorder at the Substance Abuse Treatment Unit (SATU) will be randomized to receive cognitive remediation therapy with or without additional compensation based on performance. Participants will use the computerized cognitive remediation program (PSSCogRehab 2012) three times per week for four weeks. The primary outcome measure will be an improved performance on the computerized tasks, with secondary outcomes of changes in cognitive functioning (e.g., attention, concentration, memory) as measured by neuropsychological tests between baseline and post-treatment.

Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • 18 to 60 years old
  • Primary Alcohol and/or Cocaine Abuse/Dependence Diagnosis
  • Abstinence from all drugs/alcohol for 30 days
  • Mild cognitive impairment
  • Sufficiently stable and plan to commit to 4 weeks of outpatient treatment
  • Fluent in English and 6th grade reading ability

Exclusion Criteria:

  • Severe cognitive impairment indicative of dementia
  • Untreated bipolar or psychotic disorder
  • Have current legal case pending such that incarceration during 4-week study is likely
  Contacts and Locations
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Please refer to this study by its identifier: NCT01633138

United States, Connecticut
Substance Abuse Treatment Unit
New Haven, Connecticut, United States, 06511
Sponsors and Collaborators
Yale University
Principal Investigator: Brian D Kiluk, PhD Yale School of Medicine
  More Information

Additional Information:
Responsible Party: Yale University Identifier: NCT01633138     History of Changes
Other Study ID Numbers: 1205010253
Study First Received: June 27, 2012
Last Updated: July 16, 2015

Keywords provided by Yale University:
cognitive remediation therapy
substance abuse treatment

Additional relevant MeSH terms:
Mental Disorders
Psychotic Disorders
Substance-Related Disorders
Pathologic Processes
Schizophrenia Spectrum and Other Psychotic Disorders
Chemically-Induced Disorders processed this record on May 23, 2017