Performance-based Reinforcement to Enhance Cognitive Remediation Therapy
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01633138|
Recruitment Status : Completed
First Posted : July 4, 2012
Last Update Posted : July 17, 2015
|Condition or disease||Intervention/treatment||Phase|
|Substance-Related Disorders Mental Disorders||Behavioral: Cognitive Remediation Therapy - Standard Behavioral: Cognitive Remediation Therapy plus Contingency Management||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Pilot Study of Performance-based Reinforcement to Enhance Cognitive Remediation Therapy for Substance Users|
|Study Start Date :||September 2012|
|Primary Completion Date :||December 2014|
|Study Completion Date :||December 2014|
Active Comparator: CRT-S
Cognitive Remediation Therapy - Standard
Behavioral: Cognitive Remediation Therapy - Standard
Computerized cognitive remediation therapy provided three times per week for four weeks
Cognitive Remediation Therapy plus Contingency Management
Behavioral: Cognitive Remediation Therapy plus Contingency Management
Standard cognitive remediation therapy plus monetary incentives based on performance provided three times per week for four weeks.
- Improvement in performance scores on computerized cognitive remediation tasks [ Time Frame: 4 weeks ]Performance scores on various computerized cognitive remediation tasks will be measured repeatedly during the 4 week study. These scores include "time to completion", "number of errors", "number of words correctly recalled", and "percentage of task completed"
- Improved cognitive function on neuropsychological tests [ Time Frame: 4 weeks ]Change in cognitive function between baseline and post-treatment will be measured by performance on neuropsychological tests, such as Trail Making Test A & B, Wisconsin Card Sort Test, Digit Symbol Test from WAIS-IV, and the Continuous Performance Test-II (CPT-II).
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01633138
|United States, Connecticut|
|Substance Abuse Treatment Unit|
|New Haven, Connecticut, United States, 06511|
|Principal Investigator:||Brian D Kiluk, PhD||Yale School of Medicine|