Assessment of Small Intestinal Bowel Epithelial Gaps in Irritable Bowel Syndrome
Recruitment status was Recruiting
The study aims to:
- Determine whether the density of epithelial gaps in terminal ileum of patients with irritable bowel syndrome (IBS) is different from that in inflammatory bowel disease (IBD) patients and normal controls by confocal laser endomicroscopy (CLE).
- Evaluate the relationship between the density of epithelial gaps and IBS subtypes, and visceral hypersensitivity.
Irritable Bowel Syndrome
Inflammatory Bowel Disease
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Assessment of Small Intestinal Bowel Epithelial Gaps in Patients With Irritable Bowel Syndrome by Confocal Laser Endomicroscopy|
Taken biopsies during endoscopy
|Study Start Date:||June 2012|
|Estimated Study Completion Date:||December 2012|
|Estimated Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
Irritable bowel syndrome
Patients admitted to outpatient department with symptoms meeting Rome III criteria of irritable bowel syndrome.
Patients with long standing history or short onset of inflammatory bowel disease.
Asymptomatic individuals admitted for health surveillance or patients for follow up after polypectomy.
Epithelial cells lining the gastrointestinal tract serve as a barrier between the gut lumen and the body. Previous study has shown that epithelium is punctuated by discontinuities named "gaps". Confocal laser endomicroscopy could be used as a useful tool for detecting epithelial gaps in vivo, and epithelial gap density in terminal ileum of IBD patients was elevated compared with normal control using CLE. So this study aims to determine whether the density of epithelial gaps in terminal ileum of patients with IBS is different from that in IBD patients and normal controls by CLE, and to evaluate the relationship between the density of epithelial gaps and IBS subtypes, and visceral hypersensitivity.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01632488
|Contact: Yanqing Li, MD, PhD||86-531-8216923 ext firstname.lastname@example.org|
|Facility: Department of Gastroenterology, Qilu Hospital, Shandong University||Recruiting|
|Jinan, Shandong, China, 250012|
|Contact: Yanqing Li, MD, PhD 86-531-82169236 ext 82169508 email@example.com|
|Study Director:||Yanqing Li, MD, PhD||Department of Gastroenterology, Qilu Hospital|