Prevalence of Food Allergies in a Cohort of Adult Patients With Eosinophilic Esophagitis (EE)
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|ClinicalTrials.gov Identifier: NCT01631591|
Recruitment Status : Completed
First Posted : June 29, 2012
Last Update Posted : July 10, 2018
|Condition or disease|
|Eosinophilic Esophagitis Food Allergies|
Study Population Male and female subjects, ages 18 years and older with findings of > 15 eosinophils per high powered field by endoscopic esophageal biopsy. Patients should also have symptoms consistent with eosinophilic esophagitis including dysphagia, heartburn, epigastric pain, recurrent vomiting, or food impaction. The comparative group will include male and female subjects, ages 18 years and older with a previous diagnosis of gastroesophageal reflux with findings of < 15 eosinophils per high power field by endoscopic esophageal biopsy.
- Male and female subjects 18 years and older
- Previous diagnosis of eosinophilic esophagitis with clinical symptoms including heartburn, dysphagia, vomiting, epigastric pain, recurrent vomiting, food impaction as well > 15 eosinophils per high powered field (400x magnification) by endoscopic esophageal biopsy in both the proximal and distal esophagus
- Previous diagnosis of gastroesophageal reflux with < 15 eosinophils per high powered field (400x magnification) by endoscopic biopsy
- Male and female subjects less than 18 years of age
- Pregnant female subjects
- Subjects who are receiving systemic steroids and are unable to stop prior to enrollment
- Subjects who are receiving systemic antihistamines and are unable to stop prior to enrollment
- Subjects who are unable to cooperate/comply with study procedures or communicate with investigator in order to successfully complete the study
- Subjects with severe skin disorders such as atopic dermatitis, dermatographism, or psoriasis who would be unable to complete skin or patch testing
- Subjects with an infirmity, disability, or geographical location which seems likely to prevent regular attendance for patient visit Risks Skin testing with prick methodology has a risk of systemic reaction of less than 0.1% per 40 tests, however, no deaths have been reported with this method of testing. Systemic reactions are readily treated using Injectable epinephrine with oral antihistamines and oral corticosteroids (prednisone). Patch testing has no known associated risk for development of systemic reactions. Phlebotomy is associated with a minimal risk of bleeding, significant local discomfort, and infection from the needle puncture.
Benefits Treatment options for adults with eosinophilic esophagitis are limited. Food allergies are a known contributor to this disorder in children and a better understanding of food allergies in adult subjects may provide additional treatment options.
Adverse Events and Withdrawal Criteria All subjects will be assessed for adverse events at each study visit. If any adverse events are experienced by the subject, the investigator will document the event within the subject's file and promptly report the event to the IRB. The investigators involved with this study will determine if a participant needs to be withdrawn from the study based upon the subject's health and medical history.
Sample Size Sample size estimation is based on the assumption that up to 50% of adults with eosinophilic esophagitis (EE) will have a positive skin test to food and 10% of adults without EE will have a positive skin test to food. With this assumption, a total of 40 subjects are needed, 20 per group, in order to achieve at least 80% power with two sided test at alpha level of 0.05 and beta 0.2.
|Study Type :||Observational|
|Actual Enrollment :||31 participants|
|Official Title:||Prevalence of Food Allergies in a Cohort of Adult Patients With Eosinophilic Esophagitis|
|Study Start Date :||May 2011|
|Actual Primary Completion Date :||July 2014|
|Actual Study Completion Date :||July 2014|
PATIENTS WITH A CURRENT DIAGNOSIS OF eosinophilic esophagitis.
PATIENTS WITH A DIAGNOSIS WITH GERD.
- Prevalence of food allergies in a cohort of adult patients with EE. [ Time Frame: Study to close on or around May 2014 ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01631591
|United States, Florida|
|University of South Florida|
|Tampa, Florida, United States, 33613|