The Effect of a Meal on Brain Activation in Reward Pathways (Satiety)
|ClinicalTrials.gov Identifier: NCT01631045|
Recruitment Status : Completed
First Posted : June 28, 2012
Last Update Posted : July 4, 2013
|Condition or disease|
|Brain Response to Visual Food Cues|
|Study Type :||Observational|
|Actual Enrollment :||24 participants|
|Observational Model:||Case Control|
|Official Title:||The Effect of a Meal on Brain Activation in Reward Pathways|
|Study Start Date :||April 2010|
|Primary Completion Date :||June 2012|
|Study Completion Date :||June 2012|
Subjects post-meal brain MRI will be 15 minutes after breakfast.
Subjects post-meal brain MRI will be 30 minutes after breakfast.
Subjects post-meal brain MRI will be 60 minutes after breakfast.
Subjects post-meal brain MRI will be 120 minutes after breakfast.
Subjects post-meal brain MRI will be 180 minutes after breakfast.
Subjects post-meal brain MRI will be 240 minutes after breakfast.
Subjects post-meal brain MRI will be 300 minutes after breakfast.
- BOLD response as measured by brain fMRI during viewing of food photographs [ Time Frame: We will randomly assign subjects to one of 7 timepoints for a post-meal brain MRI - 15, 30, 60, 120, 180, 240, or 300 minutes after their breakfast. ]To determine whether the change in brain response (as captured by MRI) to visual food cues with food intake is a marker of satiety. We hypothesize that consumption of a meal will reduce brain activation by food cues and that these reductions will be temporally associated with both subjective and objective measures of satiety.
- Secondary endpoints are the amount of food eaten at a lunch buffet and self-reported appetite ratings. [ Time Frame: Every 30 minutes throughout study. ]To measure subjective appetite and satiety, subjects will complete serial visual analog rating scales (VAS) of hunger and fullness every 30 minutes. We predict that the percentage change in brain activation will correlate with changes in self-reported hunger and fullness. After the post-meal scan, we will obtain measurements of objective satiety for each subject by monitoring his or her food intake during a 30 minute ad libitum buffet meal. The buffet will be surreptitiously monitored, allowing us to assess ad libitum caloric intake and food choices.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01631045
|United States, Washington|
|University of Washington Medical Center|
|Seattle, Washington, United States, 98104|
|Principal Investigator:||Ellen Schur, MD, MS||Assistant Professor|