Executive Functioning and Mindfulness in Adults With Attention Deficit/Hyperactivity Disorder Imaging (EFMImaging)
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ClinicalTrials.gov Identifier: NCT01629914 |
Recruitment Status
:
Withdrawn
(study close-out)
First Posted
: June 28, 2012
Last Update Posted
: January 31, 2017
|
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Attention-deficit/Hyperactivity Disorder | Behavioral: Mindfulness Meditation | Not Applicable |
The broad objective of this proposal is to identify functional neuroanatomical correlates of changes in executive brain functioning prior to and following an 8-week, group-based mindfulness meditation intervention within a group of 10 adults diagnosed with Attention-deficit/hyperactivity disorder (ADHD). Another group of 10 adults diagnosed with ADHD will be placed in the waitlist condition.
Our primary hypothesis is that adults with ADHD in the treatment group will exhibit improved performance on a series of executive functioning tasks and that exposure to task stimuli will correspond to changes in neural functioning following an 8-week, group-based mindfulness intervention. Brain responses will be measured using blood-oxygenation-level-dependent (BOLD) fMRI signal in brain regions associated with emotional and executive processes prior to and following treatment.
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 0 participants |
Intervention Model: | Single Group Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Other |
Official Title: | Executive Functioning and Mindfulness in Adults With ADHD Imaging |
Study Start Date : | June 2012 |
Actual Primary Completion Date : | January 2013 |
Actual Study Completion Date : | January 2013 |

-
Behavioral: Mindfulness Meditation
- change from baseline in blood-oxygenation-level-dependent (BOLD) fMRI signal [ Time Frame: baseline and 8-weeks ]Participants will be scanned prior to and following an 8-week group-based mindfulness meditation intervention

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Ages Eligible for Study: | 18 Years to 50 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- ages 18-50 years
- meet DSM-IV criteria for ADHD
- intellectual functioning ≥ 80 as assessed by an IQ screener
- generally healthy (i.e., no major medical problems)
Exclusion Criteria:
- major medical condition that would make participation unsafe (e.g., have pacemaker or other metallic implant), uncomfortable (e.g., chronic pain)
- claustrophobic, or abnormally afraid of closed-in places
- current drug use

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01629914
Principal Investigator: | John T Mitchell, Ph.D | Duke University |
Responsible Party: | Duke University |
ClinicalTrials.gov Identifier: | NCT01629914 History of Changes |
Other Study ID Numbers: |
Pro00037192 |
First Posted: | June 28, 2012 Key Record Dates |
Last Update Posted: | January 31, 2017 |
Last Verified: | January 2013 |
Keywords provided by Duke University:
Attention-deficit/hyperactivity disorder executive functioning mindfulness meditation magnetic resonance imaging healthy |
Additional relevant MeSH terms:
Attention Deficit Disorder with Hyperactivity Hyperkinesis Attention Deficit and Disruptive Behavior Disorders Neurodevelopmental Disorders Mental Disorders |
Dyskinesias Neurologic Manifestations Nervous System Diseases Signs and Symptoms |