Genetic Test in Detecting Minimal Residual Disease in Samples From Younger Patients Registered on the COG-AALL08B1 Trial
RATIONALE: Testing for minimal residual disease in blood samples from patients with acute lymphoblastic leukemia may help doctors plan better treatment.
PURPOSE: This research trial studies a genetic test in detecting minimal residual disease in samples from younger patients registered on COG-AALL08B1 trial.
Genetic: gene expression analysis
Other: flow cytometry
Other: laboratory biomarker analysis
|Study Design:||Observational Model: Case-Only
Time Perspective: Retrospective
|Official Title:||Feasibility of Minimal Residual Disease (MRD) Determination in Pediatric B-Lineage ALL Using Deep Sequencing of the Immunoglobulin Heavy Chain Locus|
- Sensitivity of deep sequencing of the immunoglobulin heavy chain locus in determining MRD in B-lineage ALL [ Designated as safety issue: No ]
|Study Start Date:||June 2012|
|Study Completion Date:||May 2016|
|Primary Completion Date:||August 2012 (Final data collection date for primary outcome measure)|
- Assess the feasibility of minimal residual disease (MRD) determination in pediatric B-lineage acute lymphoblastic leukemia (ALL) using deep sequencing of the immunoglobulin heavy chain locus.
OUTLINE: Archived blood and tumor tissue samples are analyzed for MDR using deep sequencing of immunoglobulin heavy chain locus. MDR quantification results are then compared with the flow cytometry reference methods used in COG studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01629745
|Principal Investigator:||Brent Wood, MD, PhD||Seattle Cancer Care Alliance|