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Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (U-SMART)

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ClinicalTrials.gov Identifier: NCT01628653
Recruitment Status : Completed
First Posted : June 27, 2012
Last Update Posted : June 27, 2012
Sponsor:
Collaborator:
KT Corporation
Information provided by (Responsible Party):
Ki Woong Kim, Seoul National University Bundang Hospital

Brief Summary:
The purpose of this study is to examine feasibility and efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (U-SMART) in the elderly individuals with mild cognitive impairment (MCI).

Condition or disease Intervention/treatment Phase
Mild Cognitive Impairment Device: U-SMART Phase 1

Detailed Description:
The Spaced Retrieval-based Memory Advancement and Rehabilitation Training (SMART) which consisted of 24 one-hour face-to-face sessions (Lee, Park et al. 2009) was developed based on the spaced retrieval training (SRT), which was effective in improving memory retention span of very mild to mild Alzheimer's disease patients. The Ubiquitous SMART (U-SMART) by transforming the current SMART to a self-administered program using an application working on IPAD was developed, and was examined its feasibility and efficacy in the elderly individuals with mild cognitive impairment.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 10 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Feasibility and Efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (U-SMART) on Mild Cognitive Impairment
Study Start Date : June 2011
Actual Primary Completion Date : February 2012
Actual Study Completion Date : February 2012

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: U-SMART
U-SMART (Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training)
Device: U-SMART
4-weeks' training



Primary Outcome Measures :
  1. the five-point Likert scales for satisfaction and compliance [ Time Frame: after 4-weeks treatment ]
    To evaluate the feasibility of the U-SMART, the five-point Likert scales for satisfaction and compliance were applied to all participants.

  2. Word List Memory Test of the CERAD Neuropsychological Assessment Battery [ Time Frame: after 4-weeks treatment ]
    To evaluate the efficacy of the U-SMART, the Word List Memory Test (WLMT) of the CERAD neuropsychological assessment battery was applied to all participants.


Secondary Outcome Measures :
  1. Mini-Mental State Examination (MMSE) [ Time Frame: after 4-weeks treatment ]


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Ages Eligible for Study:   55 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Aged 55-90
  • Educational level above 1 year and confirmed literacy
  • Diagnosed to mild cognitive impairment by International Working Group on Mild Cognitive Impairment
  • Clinical Dementia Rating (CDR) of 0 or 0.5

Exclusion Criteria:

  • Diagnosed to dementia by DSM-IV
  • Evidence of delirium, confusion
  • Any neurological conditions causing cognitive decline such as Parkinson's disease, brain hemorrhage, brain tumor, normal pressure hydrocephalus
  • Evidence of severe cerebrovascular pathology
  • History of loss-of-consciousness over 1 hour due to head trauma or repetitive head trauma of mild severity
  • History of substance abuse or dependence such as alcohol
  • Presence of depressive symptoms that could influence cognitive function
  • Presence of medical comorbidities that could result in cognitive decline
  • Use of medication that could influence cognitive function seriously

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01628653


Locations
Korea, Republic of
Seoul National University Bundang Hospital
Seongnam, Gyeonggi, Korea, Republic of, 463-707
Sponsors and Collaborators
Seoul National University Bundang Hospital
KT Corporation
Investigators
Principal Investigator: Ki Woong Kim, M.D., Ph.D. Seoul National University Bundang Hospital, Seong-nam, Korea

Responsible Party: Ki Woong Kim, Professor, department of neuropsychiatry, Seoul National University Bundang Hospital
ClinicalTrials.gov Identifier: NCT01628653     History of Changes
Other Study ID Numbers: 06-2011-084
First Posted: June 27, 2012    Key Record Dates
Last Update Posted: June 27, 2012
Last Verified: June 2012

Keywords provided by Ki Woong Kim, Seoul National University Bundang Hospital:
Mild cognitive impairment
Cognitive rehabilitation
Cognitive therapy
Spaced retrieval Training
Alzheimer's disease
Memory enhancement
U-healthcare

Additional relevant MeSH terms:
Cognitive Dysfunction
Cognition Disorders
Neurocognitive Disorders
Mental Disorders