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The Effect of Attention Bias Modification Training on Reducing Depressive Symptoms

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ClinicalTrials.gov Identifier: NCT01628016
Recruitment Status : Unknown
Verified June 2012 by Wenhui Yang, Hunan Normal University.
Recruitment status was:  Enrolling by invitation
First Posted : June 26, 2012
Last Update Posted : June 26, 2012
Sponsor:
Information provided by (Responsible Party):
Wenhui Yang, Hunan Normal University

Brief Summary:
The purpose of this study is to test whether attention bias modification training is an effective neurobehavioral therapy to improve depressive symptoms.That is whether attention bias modification training is superior to placebo in reducing depressive symptoms over 1 year after training.

Condition or disease Intervention/treatment Phase
Depressive Symptoms Behavioral: a word dot-probe task for training procedure Not Applicable

Detailed Description:
Attentional bias has been theorized to play a critical role in the onset and maintenance of depression. Attentional bias modification training (ABMT), an experimental paradigm that uses training to induce adaptive attentional bias, was developed to test the causal model and this has therapeutic implications in depression.To test the effect of ABMT on treatment of depressive symptoms, a randomized, double-blind, placebo and blank controlled trial is conducted in college students who are experiencing mild-to-severe symptoms of depression.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 99 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Randomized, Double-blind, Placebo-Controlled Evaluation of the Efficacy of Attentional Bias Modification Training in the Treatment of Depressive Symptoms
Study Start Date : September 2011
Estimated Primary Completion Date : October 2012
Estimated Study Completion Date : October 2012

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: Attentional bias modification training
Participants complete 8 sessions of attention bias modification training (ABMT) during a two-week period. ABMT is a modified dot probe task, in which a probe always appears in the location of neutral stimulus after the two stimuli (i.e. one is the depressive cue and the other is neutral) were simultaneously presented. In the ABMT,the probability that a probe appears in the location of neutral is 90%, and correspondingly,in the location of depressive stimuli is 10%. Each session consists of 218 trials, and the time to complete a training session is approximately 10 minutes.
Behavioral: a word dot-probe task for training procedure
During a two-week period, 8 sessions of a modified dot probe task for attentional bias modification training (ABMT) condition, 8 sessions of a classic dot probe task for placebo training (PT) condition, only assessment for blank control condition.
Placebo Comparator: Placebo training
Participants complete 8 sessions of placebo training(PT) during a two-week period. Placebo training is a classic dot probe task, in which a probe appears after either of the locations that the two stimuli (i.e. one is the depressive cue and the other is neutral) were presented, with the same frequencies. In the PT condition, each session also consists of 218 trials, and the time to complete a PT session is approximately 10 minutes as well.
Behavioral: a word dot-probe task for training procedure
During a two-week period, 8 sessions of a modified dot probe task for attentional bias modification training (ABMT) condition, 8 sessions of a classic dot probe task for placebo training (PT) condition, only assessment for blank control condition.
No Intervention: blank control
Participants only complete assessment at each point time.
Behavioral: a word dot-probe task for training procedure
During a two-week period, 8 sessions of a modified dot probe task for attentional bias modification training (ABMT) condition, 8 sessions of a classic dot probe task for placebo training (PT) condition, only assessment for blank control condition.



Primary Outcome Measures :
  1. Change in Beck Depression Inventory-II [ Time Frame: Changes from the baseline in Beck Depression Inventory-II at pre-training to 0, 2 weeks, 4 weeks, 8 weeks, 3 months , 6 months, 12 months post-training ]
    The assessment points were pretraining(baseline), posttraining and follow-up at 2-week, 4-week,8-week,3-month, 6-month and 12-month after training completion.


Secondary Outcome Measures :
  1. Changes in attentional bias score at dot-probe task, State-Trait Anxiety Inventory-Trait(STAI-T) and Rumination Response Style(RRS) [ Time Frame: Changes from pre-training to post-training in attentional bias scores, and from the baseline in STAI-T and RRS at pre-training to 0, 2weeks, 4weeks, 8weeks, 3months , 6months and 12 months post-training ]


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Ages Eligible for Study:   16 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • A score of 14 or higher on the Beck Depression Inventory-II

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01628016


Locations
China, Hunan
Department of Psychology, Hunan Normal University
Changsha, Hunan, China, 400081
Sponsors and Collaborators
Hunan Normal University
Investigators
Principal Investigator: Wenhui Yang, Ph.D Department of Psychology, Hunan Normal University

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Wenhui Yang, Department of Psychology, Hunan Normal University
ClinicalTrials.gov Identifier: NCT01628016     History of Changes
Other Study ID Numbers: XJK011AXL002
First Posted: June 26, 2012    Key Record Dates
Last Update Posted: June 26, 2012
Last Verified: June 2012

Keywords provided by Wenhui Yang, Hunan Normal University:
depression
attention
training
modification

Additional relevant MeSH terms:
Depression
Behavioral Symptoms