Continued Ventilation During Cardiopulmonary Bypass
|ClinicalTrials.gov Identifier: NCT01627756|
Recruitment Status : Completed
First Posted : June 26, 2012
Last Update Posted : June 26, 2012
|Condition or disease||Intervention/treatment||Phase|
|Coronary Artery Disease||Other: Lung Ventilation Other: Non-ventilated Group||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||30 participants|
|Intervention Model:||Parallel Assignment|
|Primary Purpose:||Basic Science|
|Official Title:||Continued Mechanical Ventilation During CABG Operation Attenuates Systemic Immune Modulation|
|Study Start Date :||April 2009|
|Actual Primary Completion Date :||August 2010|
|Actual Study Completion Date :||August 2010|
Experimental: Ventilation Group
Volume controlled ventilation was done during the whole surgery.
Other: Lung Ventilation
In the ventilated group, mechanical ventilation was done with the half of the initial tidal volume (i.e. 3-4 ml/kg, 250-300ml) during the aortic cross-clamp.
No Intervention: Non-ventilation Group
In the non-ventilated group lungs were collapsed after completion of CPB until after weaning from the extracorporeal circulation.
Other: Non-ventilated Group
. In the non-ventilated group lungs were collapsed after completion of CPB until after weaning from the extracorporeal circulation.
- Alteration of soluble ST2 concentration in serum [ Time Frame: Preoperative, postoperative, day 1, day 2, day 3, day 4, day 5 after surgery ]Concentration of soluble ST2 will be assessed in the serum of patient´s preoperativem, postoperative and the following five consecutive days after surgery.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01627756
|Medical University of Debrecen|
|Debrecen, Hungary, Nagyerdei krt. 98|
|Principal Investigator:||Hendrik Jan Ankersmit, MD||Medical University of Vienna|