Human Adaptation to High Altitude

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2012 by Zurich Center for Integrative Human Physiology.
Recruitment status was  Recruiting
Information provided by (Responsible Party):
Zurich Center for Integrative Human Physiology Identifier:
First received: May 4, 2012
Last updated: June 21, 2012
Last verified: June 2012

This scientific study aims at studying human adaptations to high altitude and the studies will be conducted at the University of Zürich and during a 4 week high altitude "expedition" to the Jungfraujoch research station at 3450 m altitude. The proposal is made up of several independent biological research projects to be conducted in the same healthy volunteers participating in the study. Thus, the subjects will be studied at sea level, and then during 4 weeks of acclimatization to high altitude, and for some experimental purposes all subjects will also be studied one and two weeks after return to sea level.

Condition Intervention
Other: altitude

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Human Adaptation to High Altitude

Further study details as provided by Zurich Center for Integrative Human Physiology:

Primary Outcome Measures:
  • Human adaptation to high altitude [ Time Frame: May-June, 2012 ] [ Designated as safety issue: No ]
    The primary outcome measure are changes in red cell blood mass, cardiac output, middle cerebral blood flow, muscle sympathetic activity and mitochondrial function.

Estimated Enrollment: 8
Study Start Date: April 2012
Estimated Study Completion Date: September 2012
Estimated Primary Completion Date: July 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: altitude
subjects will be studies at sea level and at high altitude
Other: altitude
the subjects will live one month at 3450 m altitude in the Jungfraujoch Research Station
Other Name: Jungfraujoch Research Station

  Show Detailed Description


Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • 18 to 35 yrs of age
  • male
  • healthy

Exclusion Criteria:

  • smokers
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01627652

Contact: Carsten Lundby, PhD 0041446355052

University of Zürich and the JUngfraujoch Research Station Recruiting
Zürich and Jungfraujoch (mountain), Switzerland, 8057
Contact: Carsten Lundby, PhD    0041446355052   
Sponsors and Collaborators
Zurich Center for Integrative Human Physiology
  More Information

No publications provided

Responsible Party: Zurich Center for Integrative Human Physiology Identifier: NCT01627652     History of Changes
Other Study ID Numbers: EK 2011-N-51
Study First Received: May 4, 2012
Last Updated: June 21, 2012
Health Authority: Switzerland: Ethikkommission

Keywords provided by Zurich Center for Integrative Human Physiology:
hypoxia processed this record on October 08, 2015