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Human Adaptation to High Altitude

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2012 by Zurich Center for Integrative Human Physiology.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01627652
First Posted: June 26, 2012
Last Update Posted: June 26, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Zurich Center for Integrative Human Physiology
  Purpose
This scientific study aims at studying human adaptations to high altitude and the studies will be conducted at the University of Zürich and during a 4 week high altitude "expedition" to the Jungfraujoch research station at 3450 m altitude. The proposal is made up of several independent biological research projects to be conducted in the same healthy volunteers participating in the study. Thus, the subjects will be studied at sea level, and then during 4 weeks of acclimatization to high altitude, and for some experimental purposes all subjects will also be studied one and two weeks after return to sea level.

Condition Intervention
Hypoxia Other: altitude

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Human Adaptation to High Altitude

Further study details as provided by Zurich Center for Integrative Human Physiology:

Primary Outcome Measures:
  • Human adaptation to high altitude [ Time Frame: May-June, 2012 ]
    The primary outcome measure are changes in red cell blood mass, cardiac output, middle cerebral blood flow, muscle sympathetic activity and mitochondrial function.


Estimated Enrollment: 8
Study Start Date: April 2012
Estimated Study Completion Date: September 2012
Estimated Primary Completion Date: July 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: altitude
subjects will be studies at sea level and at high altitude
Other: altitude
the subjects will live one month at 3450 m altitude in the Jungfraujoch Research Station
Other Name: Jungfraujoch Research Station

  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 18 to 35 yrs of age
  • male
  • healthy

Exclusion Criteria:

  • smokers
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01627652


Contacts
Contact: Carsten Lundby, PhD 0041446355052 carsten.lundby@access.uzh.ch

Locations
Switzerland
University of Zürich and the JUngfraujoch Research Station Recruiting
Zürich and Jungfraujoch (mountain), Switzerland, 8057
Contact: Carsten Lundby, PhD    0041446355052    carsten.lundby@access.uzh.ch   
Sponsors and Collaborators
Zurich Center for Integrative Human Physiology
  More Information

Responsible Party: Zurich Center for Integrative Human Physiology
ClinicalTrials.gov Identifier: NCT01627652     History of Changes
Other Study ID Numbers: EK 2011-N-51
First Submitted: May 4, 2012
First Posted: June 26, 2012
Last Update Posted: June 26, 2012
Last Verified: June 2012

Keywords provided by Zurich Center for Integrative Human Physiology:
hypoxia

Additional relevant MeSH terms:
Hypoxia
Signs and Symptoms, Respiratory
Signs and Symptoms