Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic Leukemia
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|ClinicalTrials.gov Identifier: NCT01626183|
Recruitment Status : Completed
First Posted : June 22, 2012
Last Update Posted : May 17, 2016
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer
PURPOSE: This laboratory study is looking into RNA in samples from younger patients with T-cell (T) acute lymphoblastic leukemia (ALL).
|Condition or disease||Intervention/treatment|
|Leukemia||Genetic: RNA analysis Genetic: proteomic profiling Other: laboratory biomarker analysis|
- Characterization of the transcriptomic landscape in diagnosis and relapse of T-cell acute lymphoblastic leukemia (ALL) and the direct comparison with corresponding physiological samples (human thymus).
- Perform high-throughput transcriptome ribonucleic acid (RNA) sequencing using matched diagnostic T-precursor pediatric ALL samples (peripheral blood or bone marrow).
OUTLINE: Archived peripheral blood and bone marrow samples are analyzed for long non-coding RNA (IncRNA) expression and sequencing.
|Study Type :||Observational|
|Estimated Enrollment :||20 participants|
|Official Title:||Molecular Taxonomy in Pediatric Cancer- IncRNA Expression in Primary T-ALL|
|Study Start Date :||May 2012|
|Actual Primary Completion Date :||May 2016|
|Actual Study Completion Date :||May 2016|
- Identification and characterization of IncRNA of pediatric T-cell acute lymphoblastic leukemia
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01626183
|Principal Investigator:||Iannis Aifantis, PhD||New York University School of Medicine|