Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic Leukemia

This study is ongoing, but not recruiting participants.
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group Identifier:
First received: June 20, 2012
Last updated: May 4, 2015
Last verified: May 2015

RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer

PURPOSE: This laboratory study is looking into RNA in samples from younger patients with T-cell (T) acute lymphoblastic leukemia (ALL).

Condition Intervention
Genetic: RNA analysis
Genetic: proteomic profiling
Other: laboratory biomarker analysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Molecular Taxonomy in Pediatric Cancer- IncRNA Expression in Primary T-ALL

Resource links provided by NLM:

Further study details as provided by Children's Oncology Group:

Primary Outcome Measures:
  • Identification and characterization of IncRNA of pediatric T-cell acute lymphoblastic leukemia [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA


Estimated Enrollment: 20
Study Start Date: June 2012
Estimated Primary Completion Date: January 2100 (Final data collection date for primary outcome measure)
Detailed Description:


  • Characterization of the transcriptomic landscape in diagnosis and relapse of T-cell acute lymphoblastic leukemia (ALL) and the direct comparison with corresponding physiological samples (human thymus).
  • Perform high-throughput transcriptome ribonucleic acid (RNA) sequencing using matched diagnostic T-precursor pediatric ALL samples (peripheral blood or bone marrow).

OUTLINE: Archived peripheral blood and bone marrow samples are analyzed for long non-coding RNA (IncRNA) expression and sequencing.


Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

pediatric patients with diagnosed or relapsed T-ALL



  • Peripheral blood and bone marrow samples from pediatric patients with diagnosed and relapsed T-ALL


  • Not specified


  • Not specified
  Contacts and Locations
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Please refer to this study by its identifier: NCT01626183

Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Iannis Aifantis, PhD New York University School of Medicine
  More Information

Additional Information:
No publications provided

Responsible Party: Children's Oncology Group Identifier: NCT01626183     History of Changes
Other Study ID Numbers: AALL12B8, COG-AALL12B8, CDR0000735509, NCI-2012-01980
Study First Received: June 20, 2012
Last Updated: May 4, 2015
Health Authority: United States: Federal Government

Keywords provided by Children's Oncology Group:
T-cell childhood acute lymphoblastic leukemia
recurrent childhood acute lymphoblastic leukemia

Additional relevant MeSH terms:
Leukemia, Lymphoid
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Immune System Diseases
Immunoproliferative Disorders
Lymphatic Diseases
Lymphoproliferative Disorders
Neoplasms by Histologic Type processed this record on October 07, 2015