Prevalence of Transthyretin Amyloidosis in Hypertrophic Cardiomyopathy (Amylo)
|ClinicalTrials.gov Identifier: NCT01623245|
Recruitment Status : Completed
First Posted : June 19, 2012
Last Update Posted : November 24, 2017
|Condition or disease|
|Cardiac Amyloidosis Amyloidosis in Transthyretin (TTR) Hypertrophic Cardiomyopathy (HCM)|
A systematic screening of TTR mutations within the MHC would diagnose cardiac amyloidosis in TTR and improve the care of patients and their families.
The detection of this disease is important because this disease is fatal and a new treatment to prevent the accumulation of TTR is now available (Tafamidis). This drug has proved effective in stabilizing neurological damage.
Depending on the number of patient with cardiac amyloidosis in TTR detected, the prospect will begin a clinical trial to test the effectiveness of a new treatment to prevent the increase in mass of the left ventricle wall objectified resonance nuclear Magnetic.
|Study Type :||Observational|
|Actual Enrollment :||294 participants|
|Official Title:||Prevalence of Transthyretin Amyloidosis in Hypertrophic Cardiomyopathy|
|Study Start Date :||June 2012|
|Actual Primary Completion Date :||December 2014|
|Actual Study Completion Date :||December 2014|
In the population of Hypertrophic Cardiomyopathy patients, patients suffering from a cardiac amyloidosis
- Number of ATTRm mutations [ Time Frame: 1 day ]Number of ATTRm mutations detected in a large population of patients with HCM.
- Genotype and clinical factors [ Time Frame: 1 day ]Identify clinical factors associated with biological and echocardiographic different HCM genotypes.
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01623245
|Henri Mondor Hospital|
|Creteil, France, 94000|
|Principal Investigator:||Thibaud DAMY||Assistance Publique - Hôpitaux de Paris|