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Plasma Adiponectin Level and Sleep Structures in Children With Prader-Willi Syndrome

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ClinicalTrials.gov Identifier: NCT01622751
Recruitment Status : Completed
First Posted : June 19, 2012
Last Update Posted : June 19, 2012
Sponsor:
Information provided by:
Samsung Medical Center

Brief Summary:

Context: Adiponectin is an adipose tissue-derived hormone with an insulin sensitizing effect, and has been related to obstructive sleep apnea syndrome. In addition, children with Prader-Willi syndrome (PWS) suffer from excessive daytime sleepiness and the abnormality of rapid eye movement (REM) sleep.

Objective: To determine if the sleep stages are related to the plasma levels of adiponectin, resistin, and RBP4 (retinol binding protein-4), and whether these relationships are influenced by age, obesity and insulin resistance.


Condition or disease
Prader-Willi Syndrome Obesity

Detailed Description:
This comparative study was carried out in 28 PWS children and 18 controls. The enrolled PWS children were volunteers out of a pool of approximately 100 PWS children followed at Samsung Medical Center [median age 8.0 years, interquartile range (7.0-10.5 years), BMI: median 24.2 kg/m2 (23.0-27.5 kg/m2)] and 18 obese healthy children [median age 9.0 years interquartile range (7.0-11.0 years), BMI: median 24.2 kg/m2 interquartile range (23.1-27.6 kg/m2)].

Study Type : Observational
Actual Enrollment : 46 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Plasma Adiponectin Level and Sleep Structures in Children With Prader-Willi Syndrome
Study Start Date : January 2007
Actual Study Completion Date : June 2007

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Ages Eligible for Study:   5 Years to 12 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The study population comprised 28 children with PWS and 18 controls. The enrolled children with PWS were volunteers from a pool of approximately 100 children with PWS followed up at the Samsung Medical Center. The controls were healthy children from several elementary and middle schools located in the southern areas of Seoul.
Criteria

Inclusion Criteria:

  • Prader Willi syndrome healthy children

Exclusion Criteria:

  • history of seizure,
  • mental or brain illness,
  • adenoidectomy,
  • tonsillectomy,
  • craniofacial anomalies and any treatment at the time of the study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01622751


Sponsors and Collaborators
Samsung Medical Center
Investigators
Principal Investigator: Dong-Kyu Jin, M.D. Samsung Medical Center, Sungkyunkwan University School of Medicine

ClinicalTrials.gov Identifier: NCT01622751     History of Changes
Other Study ID Numbers: 2006-09-055
First Posted: June 19, 2012    Key Record Dates
Last Update Posted: June 19, 2012
Last Verified: June 2012

Keywords provided by Samsung Medical Center:
REM sleep
Adiponectin
Prader-Willi syndrome

Additional relevant MeSH terms:
Prader-Willi Syndrome
Hyperphagia
Syndrome
Disease
Pathologic Processes
Intellectual Disability
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn
Obesity
Overnutrition
Nutrition Disorders
Signs and Symptoms, Digestive
Signs and Symptoms