PRevention of Acute Kidney Injury Initiated With Electronic Surveillance Enhancement (PRAISE)
|ClinicalTrials.gov Identifier: NCT01621152|
Recruitment Status : Active, not recruiting
First Posted : June 18, 2012
Last Update Posted : January 9, 2018
Introduction: Acute kidney injury (AKI) increases mortality, hospital cost, and rate of progression toward end stage kidney disease 1-4. Early diagnosis and management of AKI is known to improve the above mentioned outcomes.
Hypothesis: the investigators will design and validate an electronic surveillance tool to screen all the ICU admissions for the earlier, more efficient diagnosis of AKI and as a result improve the outcome of AKI in ICU patients.
Methods: the investigators plan to use the patient database, and AKIN (AKI network) definition to design an electronic alert system to allow clinicians discover patients who develop AKI. Then a randomized clinical trial will be conducted to compare earlier intervention (based on Kidney Disease: Improving Global Outcomes [KDIGO] guidelines) initiated by AKI sniffer alert to the conventional management provided by primary physician in ICU.
|Condition or disease||Intervention/treatment|
|Acute Kidney Injury||Other: Conventional management arm Other: AKI sniffer instigated AKI management|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||984 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Electronic Surveillance Sniffer for Early Detection and Intervention for Acute Kidney Injury: PRAISE Trial|
|Study Start Date :||June 2012|
|Estimated Primary Completion Date :||December 2019|
|Estimated Study Completion Date :||December 2020|
Conventional management arm
Patients with AKI receive standard of care in the conventional manner by the primary clinicians
Other: Conventional management arm
Based on KDIGO guidelines and as per primary physician in the ICU
Active Comparator: AKI sniffer instigated AKI management
primary clinicians for the AKI patients in this arm receive a verbal alert and reminder of KDIGO guidelines.
Other: AKI sniffer instigated AKI management
After identification of patients with AKI by the sniffer, primary physicians will be notified about the development of the syndrome and will be given a copy of the KDIGO guidelines for management of AKI.
- Change in acute kidney injury as measured by the Acute Kidney Injury Network Staging System [ Time Frame: baseline, 4 weeks ]The Acute Kidney Injury Network staging system is based on data indicating that a small change in serum creatinine influences outcome. Increases in serum creatinine or decreased urine output indicate greater kidney injury, with the stage ranging from 1 to 3. The higher the number, the greater the kidney injury.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01621152
|United States, Minnesota|
|Rochester, Minnesota, United States, 55905|
|Principal Investigator:||Kianoush Kashani, MD||Mayo Clinic|