Sleep Related Breathing Disturbances and High Altitude Pulmonary Hypertension in Kyrgyz Highlanders
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01621061 |
Recruitment Status
:
Completed
First Posted
: June 15, 2012
Last Update Posted
: May 15, 2014
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease |
---|
High Altitude Pulmonary Hypertension Sleep Apnea |
Study Type : | Observational |
Actual Enrollment : | 125 participants |
Observational Model: | Case Control |
Time Perspective: | Prospective |
Official Title: | Sleep Apnea and High Altitude Pulmonary Hypertension in Kyrgyz Highlanders |
Study Start Date : | June 2012 |
Actual Primary Completion Date : | December 2013 |
Actual Study Completion Date : | December 2013 |

Group/Cohort |
---|
High altitude pulmonary hypertension
Highlanders with high altitude pulmonary hypertension
|
High altitude control
Healthy highlanders
|
Low altitude control
Healthy lowlanders
|
- Sleep related breathing disturbances [ Time Frame: 4 months ]Nocturnal oxygen saturation and apnea/hypopnea index
- Pulmonary artery pressure [ Time Frame: 4 months ]Echocardiography
- Dyspnea [ Time Frame: 4 months ]NYHA functional class
- Vigilance [ Time Frame: 4 months ]Psychomotor vigilance
- Exercise performance [ Time Frame: 4 months ]6 min walk test
- Pulmonary function [ Time Frame: 4 months ]Spirometry
- Cerebral oxygen saturation [ Time Frame: 4 months ]Near-infrared spectroscopy
- Mountain sickness [ Time Frame: 4 months ]Quinghai chronic mountain sickness score
- Generic quality of life [ Time Frame: 4 months ]SF-36 quality of life questionnaire
- Disease specific quality of life [ Time Frame: 4 months ]Kansas City Cardiomyopathy questionnaire
- Subjective sleepiness [ Time Frame: 4 months ]Epworth sleepiness scale

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 16 Years and older (Child, Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- high altitude pulmonary hypertension confirmed by clinical presentation and systolic pulmonary artery pressure >50 mmHg measured by echocardiography at altitude of residence.
- healthy subjects (high altitude controls)
- Both genders
- Age >16 y
- Kyrgyz ethnicity
- born, raised and currently living at >2500 m
- healthy subjects currently living at <1000 m (low altitude controls)
Exclusion criteria:
- Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography
- excessive erythrocytosis
- other coexistent disorders that may interfere with the cardio-respiratory system and sleep
- regular use of medication that affects control of breathing
- heavy smoking

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01621061
Kyrgyzstan | |
National Center for Cardiology and Internal Medicine | |
Bishkek, Kyrgyzstan, 720040 |
Principal Investigator: | Konrad E Bloch, MD | University of Zurich, Switzerland | |
Principal Investigator: | Talant Sooronbaev, MD | National Center of Cardiology and Internal Medicine, Kyrgyzstan |
Responsible Party: | Konrad E. Bloch, Professor, University of Zurich |
ClinicalTrials.gov Identifier: | NCT01621061 History of Changes |
Other Study ID Numbers: |
01-7/219 |
First Posted: | June 15, 2012 Key Record Dates |
Last Update Posted: | May 15, 2014 |
Last Verified: | May 2014 |
Keywords provided by Konrad E. Bloch, University of Zurich:
high altitude illness pulmonary hypertension sleep apnea hypoxia |
Additional relevant MeSH terms:
Hypertension Hypertension, Pulmonary Lung Diseases Apnea Sleep Apnea Syndromes Altitude Sickness Vascular Diseases Cardiovascular Diseases |
Respiration Disorders Respiratory Tract Diseases Signs and Symptoms, Respiratory Signs and Symptoms Sleep Disorders, Intrinsic Dyssomnias Sleep Wake Disorders Nervous System Diseases |