Stress Echocardiography Versus Coronary Angiography for Left Main Stenosis Detection (ESTRIE-TC)

This study has been withdrawn prior to enrollment.
(No Funding)
Information provided by (Responsible Party):
Paul Farand, Universitaire de Sherbrooke Identifier:
First received: July 16, 2010
Last updated: June 24, 2013
Last verified: June 2013
Left main stenosis use to be treated by bypass but with the improvement of angioplasty techniques, an increasing number of patients are submit to left main coronary angioplasty. Consequences of left main intra stent stenosis can be disastrous yet, for the moment, no precise recommendation concerning the follow up of these patients exist. The investigators ought to determine if stress echocardiography can predict left main intra stent stenosis as well (non inferiorly)as control angiography that use to be done.

Condition Intervention
Left Main Coronary Artery Disease
Other: Stress echocardiography

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Évaluation de l'Echographie de Stress Par Comparaison à la Coronarographie Comme Outil Non Invasif de détection de la resténose Intra endoprothèse du Tronc Commun

Resource links provided by NLM:

Further study details as provided by Université de Sherbrooke:

Primary Outcome Measures:
  • Correlation between stress echocardiography results for the detection of left main prosthesis stenosis with coronary angiogram results. [ Time Frame: 9 to 12 months after left main angioplasty ] [ Designated as safety issue: No ]

Enrollment: 0
Study Start Date: July 2010
Estimated Study Completion Date: July 2013
Estimated Primary Completion Date: July 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Stress echography
Nine to twelve months after their left main angioplasty, patients will go through a stress echo and then the usual control angiography (done routinely in most patient in our center). Patients will act as their own control.
Other: Stress echocardiography
Patients able to exercise will have a treadmill test + echography; the others will have a dobutamine echography.
Other Names:
  • Dobutamine echocardiography
  • Treadmill echocardiography

Detailed Description:
All patients of the study will pass coronary angiogram and stress echocardiography (treadmill of dobutamine).

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients presenting to teaching hospital or stent from community hospitals to teaching hospital and having left main angioplasty

Inclusion Criteria:

  • patients over 18 years old able to give consent and having had left main angioplasty.

Exclusion Criteria:

  • Bypass on the left anterior descending coronary artery or left circumflex (" protected left main ")
  • Treating physician judge that angiography need to be done straightaway
  • Follow up elsewhere than the CHUS
  • Patient refusal
  • Pregnant women
  • Stress echo contraindication(Severe high blood pressure or malignant arrhythmia)or condition that limits interpretation (Left bundle branch block or pacemaker rhythm)
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Please refer to this study by its identifier: NCT01620320

Canada, Quebec
Centre Hospitalier Universitaire de Sherbrooke, departement de cardiologie
Sherbrooke, Quebec, Canada, J1H 5N4
Sponsors and Collaborators
Université de Sherbrooke
Principal Investigator: Paul Farand, Cardiologue Centre Hospitalier Universitaire de Sherbrooke
  More Information

Responsible Party: Paul Farand, Doctor, Universitaire de Sherbrooke Identifier: NCT01620320     History of Changes
Other Study ID Numbers: projet #10-011 
Study First Received: July 16, 2010
Last Updated: June 24, 2013
Health Authority: Canada: Health Canada

Keywords provided by Université de Sherbrooke:
Left main coronary artery
Coronary artery disease
Stress echography
Intrastent stenosis

Additional relevant MeSH terms:
Constriction, Pathologic
Coronary Artery Disease
Coronary Disease
Myocardial Ischemia
Arterial Occlusive Diseases
Cardiovascular Diseases
Heart Diseases
Pathological Conditions, Anatomical
Vascular Diseases processed this record on May 22, 2016