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Use Quantitative Microradiography to Predict the Periprosthetic Bone Loss in Distal Femur After Total Knee Arthroplasty

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2012 by National Taiwan University Hospital.
Recruitment status was:  Not yet recruiting
Information provided by (Responsible Party):
National Taiwan University Hospital Identifier:
First received: June 11, 2012
Last updated: June 12, 2012
Last verified: June 2012
The investigators hypothesized that the microarchitecture of bone influence the degree of periprosthetic bone loss after total knee arthroplasty surgery. The investigators collected the bone fragment at the distal femur while performing total knee replacement and take quantitative radiography analysis . Before and after the surgery(6 month ,12 month) , the investigators check the BMD at identical location of the distal femur by using dual energy absorptiometry. The investigators will use linear regression to evaluate the relationship between the microarchitecture and the degree of bone loss.

Condition Intervention
Periprosthetic Bone Loss in Total Knee Replacement
Radiation: dual energy x-ray absorptiometry

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Use Dual-energy X-ray Absorptiometry and Quantitative Microradiography to Predict the Periprosthetic Bone Loss in Distal Femur After Total Knee Arthroplasty

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • change in bone mineral density [ Time Frame: before the surgery and after the sugery (6month ,12month) ]
    Use dual energy x-ray absorptiometry to detect to BMD at the distal femur

Biospecimen Retention:   Samples With DNA
A 2X1X0.5cm bone fragment harvested during the chamfer cut of total knee arthroplasty

Estimated Enrollment: 50
Study Start Date: July 2012
Estimated Study Completion Date: July 2013
Estimated Primary Completion Date: July 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
severe knee OA who are indicated for total knee arthroplasty
the woman who are indicated for TKR and are post menopausal will be recruited in this study. We will excluded the patients who had immune disease ,previous fracture of femur and end stage of renal disease
Radiation: dual energy x-ray absorptiometry
before the surgery of total knee arthroplasty and after the surgery 6 months and 12 months


Ages Eligible for Study:   50 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
the patients who are indicated for total knee arthroplasty and are post menopausal women. The patients who had history of immune disease , fracture of the femur and end stage of renal disease will be excluded

Inclusion Criteria:

  • severe knee osteoarthritis
  • post menopausal women

Exclusion Criteria:

  • immune disease
  • end stage of renal disease who receive dialysis
  • history of fracture at ipsilateral distal femur
  Contacts and Locations
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Please refer to this study by its identifier: NCT01618149

Contact: Ching Chuan Jiang, professor 23123456 ext 65273
Contact: Wei cheng Huang, resident

National taiwan university hospital Not yet recruiting
Taipei, Taiwan, 100
Contact: Ching Chuan Jiang, professoir    886223123456 ext 65273   
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: ching chuan Jiang, professor National Taiwan University Hospital
  More Information

Responsible Party: National Taiwan University Hospital, Use dual-energy x-ray absorptiometry and quantative microradiography to predict the periprosthetic bone loss in distal femur after total knee arthroplasty Identifier: NCT01618149     History of Changes
Other Study ID Numbers: 201204035RIB
Study First Received: June 11, 2012
Last Updated: June 12, 2012

Keywords provided by National Taiwan University Hospital:
periprosthetic bone loss
dual energy x-ray absorptiometry

Additional relevant MeSH terms:
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases processed this record on May 23, 2017