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Effect of Acute Treatment With N2O on Inhibitory Pain Mechanisms in Healthy Subject (N2O)

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ClinicalTrials.gov Identifier: NCT01616004
Recruitment Status : Unknown
Verified June 2012 by Tel-Aviv Sourasky Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : June 11, 2012
Last Update Posted : September 23, 2014
Information provided by (Responsible Party):
Tel-Aviv Sourasky Medical Center

Brief Summary:
The purpose of this study is to determine whether N2O (laughing gas) has an antinociceptive effects in healthy volunteers.

Condition or disease Intervention/treatment
Pain Drug: N2O Drug: Air

Detailed Description:
10 healthy volunteers will come twice to the pain medicine unit, at 1 visit they'll get N2O and in the second visit they'll get air as placebo, they won't know what they're getting. During the visit they'll get heat stimulus using QST and will have to report their pain using eVAS (scale from 0 to 100 when 0 is no pain and 100 is the worst pain imagine).

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 10 participants
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Effect of Acute Treatment With N2O on Inhibitory Pain Mechanisms in Healthy Subject
Study Start Date : October 2014
Estimated Primary Completion Date : August 2015
Estimated Study Completion Date : August 2016

Arm Intervention/treatment
Experimental: N2O
N20 70% inhalation 5 minutes O2 100 % inhalation for 5 minutes
Drug: N2O
Other Name: laughing gas
Sham Comparator: Air Drug: Air
sham comparator

Primary Outcome Measures :
  1. Pain Scores on the Visual Analog Scale [ Time Frame: August 2016 ]

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • 18-50 years old
  • women and men
  • healthy

Exclusion Criteria:

  • smokers
  • medication use pregnant woman cardiovascular disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01616004

Contact: Silviu Brill, M.D 972-3-6974477 silviub@tasmc.health.gov.il

Tel Aviv Sourasky Medical Center, Pain Medicine Unit Not yet recruiting
Tel Aviv, Israel
Contact: silviu Brill, M.D    972-3-6974477    silviub@tasmc.health.gov.il   
Sponsors and Collaborators
Tel-Aviv Sourasky Medical Center
Principal Investigator: Silviu Brill, MD Tel-Aviv Sourasky Medical Center

Responsible Party: Tel-Aviv Sourasky Medical Center
ClinicalTrials.gov Identifier: NCT01616004     History of Changes
Other Study ID Numbers: TASMC-12-SB-340-CTIL
First Posted: June 11, 2012    Key Record Dates
Last Update Posted: September 23, 2014
Last Verified: June 2012