Detection of Micrometastases in Lymph Nodes of Patients With Prostate Cancer
The purpose of this study is to set up a model for detecting micrometastases in Lymph nodes of patients with prostate cancer by quantitative polymerase chain reaction and its impact on progression-free survival.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
|Official Title:||Detection of Micrometastases in Lymph Nodes of Patients With Prostate Cancer|
- Biochemical recurrence free survival [ Time Frame: 2 years ] [ Designated as safety issue: No ]Influence of molecularbiologic micrometastases in lymph nodes on biochemical recurrence free survival in comparison with patients who have histopathologic macrometastases or no evidence of lymph node metastases
- Frequency of molecular detected lymph node micrometastases according to their topography [ Time Frame: 2 years ] [ Designated as safety issue: No ]
Description of the anatomic distribution of molecularbiologic lymph node micrometastases in prostate cancer patients treated with radical prostatectomy and extended lymphadenectomy.
The frequency of molecular detected lymph node micrometastases according to their anatomic distribution at the obturatoric fossa, external iliac, internal iliac and common iliac arteries´ region will be reported.
|Study Start Date:||February 2010|
|Estimated Study Completion Date:||December 2021|
|Estimated Primary Completion Date:||December 2020 (Final data collection date for primary outcome measure)|
Molecular biologic detection of micrometastases in lymph nodes of patients with localized prostate cancer treated with radical prostatectomy and lymphadenectomy.
Other: tumor marker detection in lymph nodes
tumor marker detection in lymph nodes by quantitative PCR
Please refer to this study by its ClinicalTrials.gov identifier: NCT01615965
|Munich, Germany, 81675|