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Understanding and Diagnosing Allergic Disease in Twins

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ClinicalTrials.gov Identifier: NCT01613885
Recruitment Status : Recruiting
First Posted : June 7, 2012
Last Update Posted : April 5, 2018
Sponsor:
Information provided by (Responsible Party):
Kari Christine Nadeau, Stanford University

Brief Summary:
The purpose of this study is to gain better understanding of how the immune system works in twins with and without allergic disease. Healthy volunteers are not specifically targeted. Healthy non-allergic study participants may be found through the course of evaluation for the presence of allergies.

Condition or disease Intervention/treatment
Allergies Other: No Intervention

Detailed Description:
The purpose of this study is to study the genetic control and gain better understanding of how the immune system works in twins with and without allergic disease. Although healthy volunteers are not specifically targeted, they might be identified when non-allergic study participants are found through the course of evaluation for the presence of allergies.

Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Other
Time Perspective: Other
Official Title: Understanding and Diagnosing Allergic Disease in Twins
Study Start Date : August 2010
Estimated Primary Completion Date : December 2018
Estimated Study Completion Date : December 2019

Group/Cohort Intervention/treatment
Twins
Twins that are ages 0 to 80 years, with or without allergy disease.
Other: No Intervention
This study does not involve any intervention other than obtaining blood, urine, and stool samples.



Primary Outcome Measures :
  1. Comparing immune systems of food allergic twins [ Time Frame: 2 years ]
    Differences in genetic and phenotypic characteristics between twin siblings


Biospecimen Retention:   Samples With DNA
Blood


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Ages Eligible for Study:   up to 80 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy volunteers are not specifically targeted. Healthy non-allergic study participants may be found through the course of evaluation for the presence of allergies. Women, minorities or children will not be excluded from this study.
Criteria

Inclusion Criteria:

  • Twin participants ages 0 to 80 years who are with or without allergy disease.

Exclusion Criteria:

  • Patients with special risks attendant to venipuncture will be excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01613885


Contacts
Contact: Kari A Nadeau, MD, PhD snpcenterallergy.inquiry@stanford.edu

Locations
United States, California
Stanford University School of Medicine Recruiting
Stanford, California, United States, 94305
Contact       snpcenterallergy.inquiry@stanford.edu   
Principal Investigator: Kari C Nadeau, M.D., PhD.         
Stanford University Recruiting
Stanford, California, United States, 94305
Contact: Kari Nadeau, MD, PhD       snpcenterallergy.inquiry@stanford.edu   
Sponsors and Collaborators
Stanford University
Investigators
Principal Investigator: Kari Nadeau, MD, PhD Stanford University

Responsible Party: Kari Christine Nadeau, Associate Professor, Stanford University
ClinicalTrials.gov Identifier: NCT01613885     History of Changes
Other Study ID Numbers: SU-10042011-8546
First Posted: June 7, 2012    Key Record Dates
Last Update Posted: April 5, 2018
Last Verified: April 2018

Additional relevant MeSH terms:
Diseases in Twins
Disease Attributes
Pathologic Processes