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Understanding and Diagnosing Allergic Disease in Twins

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT01613885
Recruitment Status : Recruiting
First Posted : June 7, 2012
Last Update Posted : August 12, 2020
Sponsor:
Information provided by (Responsible Party):
Kari Christine Nadeau, MD PhD, Stanford University

Brief Summary:
The purpose of this study is to gain better understanding of how the immune system works in twins with and without allergic disease. Healthy volunteers are not specifically targeted. Healthy non-allergic study participants may be found through the course of evaluation for the presence of allergies.

Condition or disease Intervention/treatment
Allergies Other: No Intervention

Detailed Description:
The purpose of this study is to study the genetic control and gain better understanding of how the immune system works in twins with and without allergic disease. Although healthy volunteers are not specifically targeted, they might be identified when non-allergic study participants are found through the course of evaluation for the presence of allergies.

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Study Type : Observational
Estimated Enrollment : 430 participants
Observational Model: Other
Time Perspective: Other
Official Title: Understanding and Diagnosing Allergic Disease in Twins
Actual Study Start Date : August 2010
Estimated Primary Completion Date : December 2022
Estimated Study Completion Date : December 2022

Group/Cohort Intervention/treatment
Twins
Twins that are ages 0 to 80 years, with or without allergy disease.
Other: No Intervention
This study does not involve any intervention other than obtaining blood, nasal/cheek/throat/skin swabs, saliva, sputum, urine, and stool samples, breathing and skin tests.




Primary Outcome Measures :
  1. Comparing immune systems of food allergic twins [ Time Frame: 2 years ]
    Differences in genetic and phenotypic characteristics between twin siblings


Biospecimen Retention:   Samples With DNA
Blood, nasal /cheek/throat/skin swab, saliva, urine, stool, sputum


Information from the National Library of Medicine

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Ages Eligible for Study:   up to 80 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy volunteers are not specifically targeted. Healthy non-allergic study participants may be found through the course of evaluation for the presence of allergies. Women, minorities or children will not be excluded from this study.
Criteria

Inclusion Criteria:

  • Twin participants ages 0 to 80 years who are with or without allergy disease.

Exclusion Criteria:

  • Patients with special risks attendant to venipuncture will be excluded.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01613885


Contacts
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Contact: Kari A Nadeau, MD, PhD 650-521-7237 snpcenterallergy.inquiry@stanford.edu

Locations
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United States, California
Sean N Parker Center for Allergy and Asthma Research at Stanford Recruiting
Stanford, California, United States, 94305
Contact: Kari Nadeau, MD, PhD       snpcenterallergy.inquiry@stanford.edu   
Stanford University School of Medicine Recruiting
Stanford, California, United States, 94305
Contact       snpcenterallergy.inquiry@stanford.edu   
Principal Investigator: Kari C Nadeau, M.D., PhD.         
Sponsors and Collaborators
Stanford University
Investigators
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Principal Investigator: Kari Nadeau, MD, PhD Stanford University
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Responsible Party: Kari Christine Nadeau, MD PhD, Associate Professor, Stanford University
ClinicalTrials.gov Identifier: NCT01613885    
Other Study ID Numbers: SU-10042011-8546
First Posted: June 7, 2012    Key Record Dates
Last Update Posted: August 12, 2020
Last Verified: August 2020
Additional relevant MeSH terms:
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Diseases in Twins
Disease Attributes
Pathologic Processes