Analysis of Fel d 1-specific T Cells After Airway Allergen Challenge in Asthma
|ClinicalTrials.gov Identifier: NCT01612715|
Recruitment Status : Unknown
Verified March 2015 by Gail Gauvreau, Hamilton Health Sciences Corporation.
Recruitment status was: Recruiting
First Posted : June 6, 2012
Last Update Posted : March 20, 2015
|Condition or disease||Intervention/treatment|
|Allergic Asthma.||Other: Segmental Allergen Challenge|
|Study Type :||Observational|
|Estimated Enrollment :||48 participants|
|Official Title:||Analysis of Fel d 1-specific T Cells After Airway Allergen Challenge in Asthma:Frequency and Phenotype and Trafficking of Cat Allergen-specific T-cells in Blood, Bone Marrow and Bronchoalveolar Lavage Fluid (BALF) Following Segmental Allergen Challenge in Allergic Asthma.|
|Study Start Date :||January 2014|
|Estimated Primary Completion Date :||April 2017|
|Estimated Study Completion Date :||April 2017|
Mild asthma, cat-allergic, 18-65 years old, males and females will be recruited for the study.
Other: Segmental Allergen Challenge
segmental allergen challenge
- Comparison [ Time Frame: 5 Years ]The primary outcome for Aim 1 of the study is to compare the number of tetramer+ T cells in the airways of early and dual-responder subjects after segmental allergen challenge. The primary outcome for Aim 2 of the study is to compare the number of tetramer+ T cells in the bone marrow of early and dual-responder subjects after segmental allergen challenge. This will be measured using a panel of antibodies and flow cytometric analysis of cell surface markers.
- Measurements [ Time Frame: 5 Years ]The secondary outcome is to determine the frequency, memory phenotype and chemokine receptor profile of tetramer+ T cells in the peripheral blood before and after bronchial allergen challenge.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01612715
|Contact: Gail Gauvreau, PhD||905-525-9140 ext firstname.lastname@example.org|
|McMaster University Medical Centre||Recruiting|
|Hamilton, Ontario, Canada, L8S 4K1|
|Contact: Gail Gauvreau, PhD 905-525-9140 ext 22791 email@example.com|
|Sub-Investigator: Paul O'Byrne, MD|
|Sub-Investigator: Kieran Killian, MD|
|Sub-Investigator: Helen Neighbour, MD|
|Sub-Investigator: Mark Larche, PhD|
|Principal Investigator:||Gail Gauvreau, PhD||McMaster University|