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Effects of Glucose-fructose Drinks During Training on Lactate Transport (LactEx)

This study has been completed.
Centre Hospitalier Universitaire Vaudois
Information provided by (Responsible Party):
Luc Tappy, MD, University of Lausanne Identifier:
First received: May 23, 2012
Last updated: June 3, 2014
Last verified: June 2014
The purpose of this study is to determine whether glucose-fructose intake during training increases lactate transport and oxidation and improve endurance performance.

Condition Intervention
Normal Physiology on Healthy Subjects
Dietary Supplement: Glucose-fructose
Dietary Supplement: Water

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Effects of Glucose-fructose Drinks During Training on Lactate Transport and Oxidation and on Endurance Performance

Resource links provided by NLM:

Further study details as provided by University of Lausanne:

Primary Outcome Measures:
  • Change in lactate transport [ Time Frame: At baseline (before training) and after the 3-week training protocol ]
    Measurement of lactate production, utilization, oxidation and clearance during a 90 min cycling exercise at 50% VO2 max (measured with 13C-lactate)

Secondary Outcome Measures:
  • Change in muscle monocarboxylate transporters (MCTs) expression and protein content [ Time Frame: At baseline (before training) and after the 3-week training protocol ]
    MCTs expression (mRNA) and protein content after muscle biopsy

Enrollment: 17
Study Start Date: May 2012
Study Completion Date: March 2014
Primary Completion Date: March 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Glucose-fructose
Participants will take glucose-fructose drinks during training sessions
Dietary Supplement: Glucose-fructose
0.8 g/h glucose and 0.5 g/h fructose during training
Experimental: Water
Participants will take only water during training sessions
Dietary Supplement: Water
Only water intake during training

Detailed Description:
The study will enroll 24 healthy male volunteers. After baseline assessment of lactate transport and endurance performance, subjects will be randomized to either a 3-week intervention arm in which they will train with glucose-fructose intake during training, or to a control arm (water during training). After this 3-week intervention, lactate transport and endurance performance will be assessed again.

Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy
  • age between 18 and 30 years
  • sedentary
  • BMI between 19 and 25
  • blood pressure lower than 140/90 mmHg

Exclusion Criteria:

  • smoking
  • consumption of more than 10g alcohol per day
  • cardiovascular history
  • electrographic abnormalities at rest
  • consumption of more than one can of soda per day or more than 60g sugars per day
  • any current drug treatment
  • consumption of drugs or illicit substances
  • diabetes mellitus
  • vegetarian
  • food intolerance
  • blood donation or participation to another study <3 months before study inclusion
  Contacts and Locations
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Please refer to this study by its identifier: NCT01610986

University of Lausanne
Lausanne, Vaud, Switzerland, 1005
Sponsors and Collaborators
University of Lausanne
Centre Hospitalier Universitaire Vaudois
Principal Investigator: Luc Tappy, Pr University of Lausanne
  More Information

Responsible Party: Luc Tappy, MD, Professor of Physiology, University of Lausanne Identifier: NCT01610986     History of Changes
Other Study ID Numbers: 251/11
Study First Received: May 23, 2012
Last Updated: June 3, 2014

Keywords provided by University of Lausanne:
Lactic acid
Monocarboxylic Acid Transporters processed this record on April 28, 2017