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Prospective Randomized Study of Glucocorticoids in the Impact of the Liver Function and the Prognosis After Hepatectomy of HCC

This study has suspended participant recruitment.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01608945
First Posted: May 31, 2012
Last Update Posted: May 31, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
jian zhai, Eastern Hepatobiliary Surgery Hospital
  Purpose
The major drawback of hepatic pedicle clamping is ischaemia-reperfusion injury with impairment of liver function. Perioperative steroid administration has been advocated to reduce liver damage. The aim of this prospective, randomized study was to determine whether steroid administration can reduce liver injury and impact the prognosis

Condition Intervention
Some Studies Shows That the Steroid Can Reduce the Injury of the I/R of the Liver Drug: Hydrocortisone sodium succinate

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by jian zhai, Eastern Hepatobiliary Surgery Hospital:

Primary Outcome Measures:
  • liver function [ Time Frame: six months ]

Enrollment: 60
Study Start Date: April 2008
Groups/Cohorts Assigned Interventions
steroid,liver function I/R Drug: Hydrocortisone sodium succinate
100mg/day

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
60
Criteria

Inclusion Criteria:

  • 18-70 years old
  • diametre of the mass>3cm.
  • hcc
  Contacts and Locations
No Contacts or Locations Provided
  More Information

Responsible Party: jian zhai, hepatic department, Eastern Hepatobiliary Surgery Hospital
ClinicalTrials.gov Identifier: NCT01608945     History of Changes
Other Study ID Numbers: EHBH112
First Submitted: May 29, 2012
First Posted: May 31, 2012
Last Update Posted: May 31, 2012
Last Verified: May 2012

Keywords provided by jian zhai, Eastern Hepatobiliary Surgery Hospital:
steroid
liver function
prognosis

Additional relevant MeSH terms:
Hydrocortisone 17-butyrate 21-propionate
Hydrocortisone acetate
Cortisol succinate
Hydrocortisone
Anti-Inflammatory Agents