Meta-analyses of Total and Individual Fructose-containing Sugars and Incident Cardiometabolic Disease
This study is ongoing, but not recruiting participants.
First Posted: May 31, 2012
Last Update Posted: May 17, 2016
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Calorie Control Council
Canada Research Chairs Endowment of the Federal Government of Canada
Canadian Institutes of Health Research (CIHR)
Information provided by (Responsible Party):
John Sievenpiper, University of Toronto
Since uncontrolled observational studies first linked fructose to the epidemic of obesity almost a decade ago, it has become a focus of intense concern regarding its role in the obesity epidemic and increasing burden of cardiometabolic disease. Despite the uncertainties in the evidence, international health organizations have cautioned against moderate to high intakes fructose-containing sugars, especially those from sugar sweetened beverages (SSBs). To improve the evidence on which nutrition recommendations are based, the investigators propose to study of the role of fructose-containing sugars in the development of overweight/obesity, diabetes, hypertension, gout, and cardiovascular disease, by undertaking a series of systematic syntheses of the available prospective cohort studies. Prospective cohort studies have the advantage of relating "real world" intakes of sugars to clinically meaningful disease endpoints over long durations of follow-up. The findings generated by this proposed knowledge synthesis will help improve the health of consumers through informing recommendations for the general public, as well as those at risk of diabetes and cardiovascular disease.
Coronary Heart Disease
||Time Perspective: Prospective
||The Relation of Total and Individual Fructose-containing Sugars With Incident Cardiometabolic Diseases: A Series of Systematic Reviews and Meta-analyses of Prospective Observational Studies
Primary Outcome Measures:
- Overweight/obesity analysis [ Time Frame: up to 1.5-years ]
Risk ratios for incident Overweight and obesity by total fructose-containing sugar exposure
- Diabetes/metabolic syndrome analysis [ Time Frame: Up to 1.5-years ]
Risk ratios for incident diabetes and metabolic syndrome by total fructose-containing sugar exposure
- Hypertension analsysis [ Time Frame: Up to 1.5-years ]
Risk ratios for incident hypertension by total fructose-containing sugar exposure
- Gout analysis [ Time Frame: Up to 1.5-years ]
Risk ratios for incident gout by total fructose-containing sugar exposure
- Coronary heart disease (CHD) analysis [ Time Frame: Up to 1.5-years ]
Risk ratios for incident CHD by total fructose-containing sugar exposure
| Estimated Enrollment:
| Study Start Date:
| Estimated Study Completion Date:
| Primary Completion Date:
||September 2014 (Final data collection date for primary outcome measure)