Database for Clinical and Anamnestic Data in Pulmonary Hypertension
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ClinicalTrials.gov Identifier: NCT01607502 |
Recruitment Status
:
Recruiting
First Posted
: May 30, 2012
Last Update Posted
: August 9, 2017
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Pulmonary hypertension (PH) is defined as a pulmonary arterial mean pressure (meanPAP) ≥ 25 mmHg measured in the right heart catheterization.
There are different forms of PH defined in the classification of Dana Point 2008.
PH is diagnosed with right heart catheterization but there are other non invasive methods which can be used for screening like the echocardiography, stress echocardiography and cardio pulmonary exercise testing. In the diagnosis process and in the follow up of PH patients biomarkers like NTproBNP are helpful. There are no specific biomarkers for the disease which can make the diagnosis process easier and predict prognosis.
The systematic data collection in a data base provides better information about patients in daily routine and clinical studies as well as in the design of new studies.
Condition or disease |
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Pulmonary Hypertension |
In this study the investigators want to collect clinical data of PH patients and controls in a database as well as blood samples in a biobank. The combination of anamnestic and clinical data and biomarkers should provide a better characterization of our patients and should improve the analysis of the disease development of different PH forms and therapeutic aspects.
After given informed consent patients' data are entered in a database at different time points. The database includes parameter of several invasive and non-invasive investigations like right heart catheterization (RHC), echocardiography, ECG, pulmonary function tests, cardiorespiratory exercise testing, 6-minute walk test, computed tomography, MRI, polysomnography, blood gas analysis and laboratory data as well as demographic data of the patients.
The blood samples are taken during routine punctuation and are stored in our biobank.
Study Type : | Observational |
Estimated Enrollment : | 900 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Database for Clinical and Anamnestic Data in Pulmonary Hypertension |
Study Start Date : | July 2010 |
Estimated Primary Completion Date : | July 2024 |
Estimated Study Completion Date : | July 2024 |

Group/Cohort |
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Patients of our outpatient clinic
Patients who have an investigation in our outpatient clinic for pulmonary hypertension like a echocardiography, a right heart catheterization or a cardio pulmonary exercise testing
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- Collecting data in a PH patient database [ Time Frame: After one year: first analysis of retrospectively collected data. Ongoing data collection: new data of patients who are already in the database, new patients (3-4 years) ]Retrospective and prospective data input and constant update
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- patients with pulmonary hypertension
- patients at risk for getting pulmonary hypertension
- patients who have symptoms which my be due to pulmonary hypertension when we have their written informed consent.
Exclusion Criteria:
- patients without written informed consent

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01607502
Contact: Horst Olschewski, MD | +43-316-385-12183 | horst.olschewski@medunigraz.at | |
Contact: Maria Tscherner, MD | +43-316-385-12183 | m.tscherner@medunigraz.at |
Austria | |
Medical University of Graz | Recruiting |
Graz, Austria, 8010 | |
Contact: Horst Olschewski, MD +43-316-385-12183 horst.olschewski@medunigraz.at | |
Contact: Maria Tscherner, MD +43-316-385-12183 m.tscherner@medunigraz.at | |
Principal Investigator: Horst Olschewski, MD |
Principal Investigator: | Horst Olschewski, MD | Medical University of Graz |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Medical University of Graz |
ClinicalTrials.gov Identifier: | NCT01607502 History of Changes |
Other Study ID Numbers: |
23-408 ex 10/11 |
First Posted: | May 30, 2012 Key Record Dates |
Last Update Posted: | August 9, 2017 |
Last Verified: | August 2017 |
Keywords provided by Medical University of Graz:
Pulmonary hypertension database biomarker |
Additional relevant MeSH terms:
Hypertension Hypertension, Pulmonary Vascular Diseases |
Cardiovascular Diseases Lung Diseases Respiratory Tract Diseases |