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Noninvasive Measurement of Cardiac Output in Pulmonary Hypertension Using Inert Gas Rebreathing

This study has been completed.
Ludwig Boltzmann Gesellschaft
Information provided by (Responsible Party):
Medical University of Graz Identifier:
First received: May 24, 2012
Last updated: February 18, 2014
Last verified: February 2014
The study hypothesis is that accuracy of CO measurement by IGR does not differ from classical CO measurement methods such as thermodilution or direct Fick method. This is why the study aims to determine whether non invasive cardiac output (CO) measurement using inert gas rebreathing (IGR)is a suitable method in patients with pulmonary hypertension. In order to examine this, the IGR method will be used in patients undergoing diagnostic or follow-up right heart catheterization.

Pulmonary Hypertension

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Noninvasive Measurement of Cardiac Output in Pulmonary Hypertension Using Inert Gas Rebreathing

Resource links provided by NLM:

Further study details as provided by Medical University of Graz:

Primary Outcome Measures:
  • Cardiac output [ Time Frame: at baseline ]

Enrollment: 34
Study Start Date: February 2012
Study Completion Date: February 2014
Primary Completion Date: February 2014 (Final data collection date for primary outcome measure)
Detailed Description:

Inert Gas Rebreathing method enables non invasive measurement of cardiac output (CO) using the single rebreathing method. A mixture of blood soluble (N2O) and blood insoluble gas (SF6) and environmental air is inhaled and the amount of N2O, SF6, O2 and CO2 is measured by a photoacoustic analysator. The length of a measurement is about 1 minute.

As the gold standard measurement of CO is performed invasively, there is an urgent need for the development of non-invasive tools like IGR.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The study population consists of patients undergoing diagnostic or follow-up right heart cathereization.

Inclusion Criteria:

  • Written informed consent
  • Patients who undergo right heart catheterization

Exclusion Criteria:

  • Missing written informed consent
  Contacts and Locations
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Please refer to this study by its identifier: NCT01606839

Ludwig Boltzmann Institute for Lung Vascular Research
Graz, Austria
Sponsors and Collaborators
Medical University of Graz
Ludwig Boltzmann Gesellschaft
Principal Investigator: Horst Olschewski, MD Medical University of Graz
  More Information

Responsible Party: Medical University of Graz Identifier: NCT01606839     History of Changes
Other Study ID Numbers: 24-079 ex 11/12
Study First Received: May 24, 2012
Last Updated: February 18, 2014

Additional relevant MeSH terms:
Hypertension, Pulmonary
Vascular Diseases
Cardiovascular Diseases
Lung Diseases
Respiratory Tract Diseases processed this record on May 25, 2017